Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117797684> ?p ?o ?g. }
- W2117797684 endingPage "2838" @default.
- W2117797684 startingPage "2828" @default.
- W2117797684 abstract "Group II introns aI1 and aI2 of the yeast mitochondrial COXI gene are mobile elements that encode an intron-specific reverse transcriptase (RT) activity. We show here that the introns of Saccharomyces cerevisiae ID41-6/161 insert site specifically into intronless alleles. The mobility is accompanied by efficient, but highly asymmetric, coconversion of nearby flanking exon sequences. Analysis of mutants shows that the aI2 protein is required for the mobility of both aI1 and aI2. Efficient mobility is dependent on both the RT activity of the aI2-encoded protein and a separate function, a putative DNA endonuclease, that is associated with the Zn2+ finger-like region of the intron reading frame. Surprisingly, there appear to be two mobility modes: the major one involves cDNAs reverse transcribed from unspliced precursor RNA; the minor one, observed in two mutants lacking detectable RT activity, appears to involve DNA level recombination. A cis-dominant splicing-defective mutant of aI2 continues to synthesize cDNAs containing the introns but is completely defective in both mobility modes, indicating that the splicing or the structure of the intron is required. Our results demonstrate that the yeast group II intron aI2 is a retroelement that uses novel mobility mechanisms." @default.
- W2117797684 created "2016-06-24" @default.
- W2117797684 creator A5005654587 @default.
- W2117797684 creator A5005988075 @default.
- W2117797684 creator A5016025349 @default.
- W2117797684 creator A5061324886 @default.
- W2117797684 creator A5072114316 @default.
- W2117797684 creator A5081127241 @default.
- W2117797684 creator A5081415562 @default.
- W2117797684 date "1995-05-01" @default.
- W2117797684 modified "2023-09-28" @default.
- W2117797684 title "Mobile Group II Introns of Yeast Mitochondrial DNA Are Novel Site-Specific Retroelements" @default.
- W2117797684 cites W128646142 @default.
- W2117797684 cites W1554644662 @default.
- W2117797684 cites W1591250963 @default.
- W2117797684 cites W1667878902 @default.
- W2117797684 cites W1980258137 @default.
- W2117797684 cites W1984298556 @default.
- W2117797684 cites W1986319478 @default.
- W2117797684 cites W1991333931 @default.
- W2117797684 cites W1998439227 @default.
- W2117797684 cites W2003217222 @default.
- W2117797684 cites W2008954911 @default.
- W2117797684 cites W2009581957 @default.
- W2117797684 cites W2015831954 @default.
- W2117797684 cites W2018050027 @default.
- W2117797684 cites W2020383739 @default.
- W2117797684 cites W2020556436 @default.
- W2117797684 cites W2025208167 @default.
- W2117797684 cites W2034252391 @default.
- W2117797684 cites W2035776094 @default.
- W2117797684 cites W2039072605 @default.
- W2117797684 cites W2053199483 @default.
- W2117797684 cites W2054778338 @default.
- W2117797684 cites W2061054814 @default.
- W2117797684 cites W2066650456 @default.
- W2117797684 cites W2067702208 @default.
- W2117797684 cites W2068183729 @default.
- W2117797684 cites W2071006290 @default.
- W2117797684 cites W2079837880 @default.
- W2117797684 cites W2081209960 @default.
- W2117797684 cites W2081585453 @default.
- W2117797684 cites W2084567923 @default.
- W2117797684 cites W2090669079 @default.
- W2117797684 cites W2092318778 @default.
- W2117797684 cites W2095919862 @default.
- W2117797684 cites W2118017429 @default.
- W2117797684 cites W2118533974 @default.
- W2117797684 cites W2175234727 @default.
- W2117797684 doi "https://doi.org/10.1128/mcb.15.5.2828" @default.
- W2117797684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/230514" @default.
- W2117797684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7537853" @default.
- W2117797684 hasPublicationYear "1995" @default.
- W2117797684 type Work @default.
- W2117797684 sameAs 2117797684 @default.
- W2117797684 citedByCount "114" @default.
- W2117797684 countsByYear W21177976842012 @default.
- W2117797684 countsByYear W21177976842014 @default.
- W2117797684 countsByYear W21177976842015 @default.
- W2117797684 countsByYear W21177976842016 @default.
- W2117797684 countsByYear W21177976842017 @default.
- W2117797684 countsByYear W21177976842018 @default.
- W2117797684 countsByYear W21177976842019 @default.
- W2117797684 countsByYear W21177976842020 @default.
- W2117797684 countsByYear W21177976842021 @default.
- W2117797684 countsByYear W21177976842023 @default.
- W2117797684 crossrefType "journal-article" @default.
- W2117797684 hasAuthorship W2117797684A5005654587 @default.
- W2117797684 hasAuthorship W2117797684A5005988075 @default.
- W2117797684 hasAuthorship W2117797684A5016025349 @default.
- W2117797684 hasAuthorship W2117797684A5061324886 @default.
- W2117797684 hasAuthorship W2117797684A5072114316 @default.
- W2117797684 hasAuthorship W2117797684A5081127241 @default.
- W2117797684 hasAuthorship W2117797684A5081415562 @default.
- W2117797684 hasBestOaLocation W21177976842 @default.
- W2117797684 hasConcept C104317684 @default.
- W2117797684 hasConcept C143065580 @default.
- W2117797684 hasConcept C36823959 @default.
- W2117797684 hasConcept C54355233 @default.
- W2117797684 hasConcept C54458228 @default.
- W2117797684 hasConcept C552990157 @default.
- W2117797684 hasConcept C64962909 @default.
- W2117797684 hasConcept C67705224 @default.
- W2117797684 hasConcept C86803240 @default.
- W2117797684 hasConcept C94671646 @default.
- W2117797684 hasConceptScore W2117797684C104317684 @default.
- W2117797684 hasConceptScore W2117797684C143065580 @default.
- W2117797684 hasConceptScore W2117797684C36823959 @default.
- W2117797684 hasConceptScore W2117797684C54355233 @default.
- W2117797684 hasConceptScore W2117797684C54458228 @default.
- W2117797684 hasConceptScore W2117797684C552990157 @default.
- W2117797684 hasConceptScore W2117797684C64962909 @default.
- W2117797684 hasConceptScore W2117797684C67705224 @default.
- W2117797684 hasConceptScore W2117797684C86803240 @default.
- W2117797684 hasConceptScore W2117797684C94671646 @default.
- W2117797684 hasIssue "5" @default.
- W2117797684 hasLocation W21177976841 @default.
- W2117797684 hasLocation W21177976842 @default.