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• W2117807589 abstract "We report the identification of a TRAF-interacting protein, T6BP, that specifically associates with TRAF6. This interaction occurs between the coiled-coil region of T6BP and the N-terminal ring finger and zinc finger domains of TRAF6. IL-1, but not tumor necrosis factor, induces TRAF6–T6BP complex formation in a ligand-dependent manner. Formation of the TRAF6–T6BP complex depends on the presence of the IL-1 receptor-associated kinase (IRAK). After IL-1 stimulation, TRAF6 can exist in two separate complexes, TRAF6–IRAK or TRAF6–T6BP, but IRAK is not present in TRAF6–T6BP complexes. T6BP does not seem to play a direct role in activation of IκB kinases or Jun N-terminal kinase." @default.
• W2117807589 created "2016-06-24" @default.
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• W2117807589 date "2000-08-01" @default.
• W2117807589 modified "2023-10-03" @default.
• W2117807589 title "T6BP, a TRAF6-interacting protein involved in IL-1 signaling" @default.
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• W2117807589 doi "https://doi.org/10.1073/pnas.170279097" @default.
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