FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117831271> ?p ?o ?g. }

• W2117831271 endingPage "2060" @default.
• W2117831271 startingPage "2048" @default.
• W2117831271 abstract "Connector enhancer of KSR (CNK) is a multidomain protein that participates in Ras signaling in Drosophila eye development. In this report we identify the human homologue of CNK, termed CNK2A, and a truncated alternatively spliced variant, CNK2B. We characterize CNK2 phosphorylation, membrane localization, and interaction with Ras effector molecules. Our results show that MAPK signaling appears to play a role in the phosphorylation of CNK2 in vivo. CNK2 is found in both membrane and cytoplasmic fractions of the cell. In MDCK cells, full-length CNK2 is localized to the lateral plasma membrane. Consistent with previous reports, we show CNK2 interacts with Raf. CNK2 interaction was mapped to the regulatory and kinase domains of Raf, as well as to the carboxyl-terminal half of CNK2. CNK2 also interacts with the Ral signaling components, Ral GTPase, and the RalGDS family member Rlf. CNK2 interaction was mapped to the GEF domain of Rlf. The ability of CNK2 to interact with both Ras effector proteins Raf and Rlf suggests that CNK2 may integrate signals between MAPK and Ral pathways through a complex interplay of components." @default.
• W2117831271 created "2016-06-24" @default.
• W2117831271 creator A5005919966 @default.
• W2117831271 creator A5012580765 @default.
• W2117831271 creator A5037621688 @default.
• W2117831271 creator A5037736308 @default.
• W2117831271 creator A5068110148 @default.
• W2117831271 creator A5089795229 @default.
• W2117831271 date "2003-11-01" @default.
• W2117831271 modified "2023-10-17" @default.
• W2117831271 title "Human homologue of<i>Drosophila</i>CNK interacts with Ras effector proteins Raf and Rlf¹" @default.
• W2117831271 cites W1640618846 @default.
• W2117831271 cites W1838131144 @default.
• W2117831271 cites W1928407971 @default.
• W2117831271 cites W1966490749 @default.
• W2117831271 cites W1967218150 @default.
• W2117831271 cites W1972239225 @default.
• W2117831271 cites W1972812612 @default.
• W2117831271 cites W1977254586 @default.
• W2117831271 cites W1980952363 @default.
• W2117831271 cites W1988409513 @default.
• W2117831271 cites W1994685933 @default.
• W2117831271 cites W1996223704 @default.
• W2117831271 cites W2016955301 @default.
• W2117831271 cites W2017146048 @default.
• W2117831271 cites W2017194364 @default.
• W2117831271 cites W2019184486 @default.
• W2117831271 cites W2024616932 @default.
• W2117831271 cites W2029744627 @default.
• W2117831271 cites W2039168276 @default.
• W2117831271 cites W2039750761 @default.
• W2117831271 cites W2047604959 @default.
• W2117831271 cites W2052122921 @default.
• W2117831271 cites W2057392977 @default.
• W2117831271 cites W2060840912 @default.
• W2117831271 cites W2068842251 @default.
• W2117831271 cites W2072243374 @default.
• W2117831271 cites W2074303585 @default.
• W2117831271 cites W2077086907 @default.
• W2117831271 cites W2078948761 @default.
• W2117831271 cites W2079618910 @default.
• W2117831271 cites W2086419819 @default.
• W2117831271 cites W2095855911 @default.
• W2117831271 cites W2099267053 @default.
• W2117831271 cites W2112879240 @default.
• W2117831271 cites W2139112892 @default.
• W2117831271 cites W2151542719 @default.
• W2117831271 cites W2152995924 @default.
• W2117831271 cites W2156875265 @default.
• W2117831271 cites W2160696180 @default.
• W2117831271 cites W2322829624 @default.
• W2117831271 cites W4230279981 @default.
• W2117831271 doi "https://doi.org/10.1096/fj.02-1096com" @default.
• W2117831271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14597674" @default.
• W2117831271 hasPublicationYear "2003" @default.
• W2117831271 type Work @default.
• W2117831271 sameAs 2117831271 @default.
• W2117831271 citedByCount "51" @default.
• W2117831271 countsByYear W21178312712012 @default.
• W2117831271 countsByYear W21178312712013 @default.
• W2117831271 countsByYear W21178312712014 @default.
• W2117831271 countsByYear W21178312712015 @default.
• W2117831271 countsByYear W21178312712016 @default.
• W2117831271 countsByYear W21178312712017 @default.
• W2117831271 countsByYear W21178312712019 @default.
• W2117831271 countsByYear W21178312712020 @default.
• W2117831271 countsByYear W21178312712021 @default.
• W2117831271 countsByYear W21178312712022 @default.
• W2117831271 countsByYear W21178312712023 @default.
• W2117831271 crossrefType "journal-article" @default.
• W2117831271 hasAuthorship W2117831271A5005919966 @default.
• W2117831271 hasAuthorship W2117831271A5012580765 @default.
• W2117831271 hasAuthorship W2117831271A5037621688 @default.
• W2117831271 hasAuthorship W2117831271A5037736308 @default.
• W2117831271 hasAuthorship W2117831271A5068110148 @default.
• W2117831271 hasAuthorship W2117831271A5089795229 @default.
• W2117831271 hasBestOaLocation W21178312712 @default.
• W2117831271 hasConcept C104317684 @default.
• W2117831271 hasConcept C108636557 @default.
• W2117831271 hasConcept C111936080 @default.
• W2117831271 hasConcept C11960822 @default.
• W2117831271 hasConcept C150194340 @default.
• W2117831271 hasConcept C184235292 @default.
• W2117831271 hasConcept C190062978 @default.
• W2117831271 hasConcept C196347352 @default.
• W2117831271 hasConcept C207332259 @default.
• W2117831271 hasConcept C2780298669 @default.
• W2117831271 hasConcept C51785407 @default.
• W2117831271 hasConcept C54355233 @default.
• W2117831271 hasConcept C57074206 @default.
• W2117831271 hasConcept C62478195 @default.
• W2117831271 hasConcept C86803240 @default.
• W2117831271 hasConcept C95444343 @default.
• W2117831271 hasConceptScore W2117831271C104317684 @default.
• W2117831271 hasConceptScore W2117831271C108636557 @default.
• W2117831271 hasConceptScore W2117831271C111936080 @default.
• W2117831271 hasConceptScore W2117831271C11960822 @default.
• W2117831271 hasConceptScore W2117831271C150194340 @default.

• next