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- W2117843685 abstract "An ideal instrument for the assessment of health related quality of life (HRQOL) in patients with diabetes mellitus type I (T1DM) should incorporate the benefits of both generic and disease-specific instruments. The objective of this study was to investigate the responsiveness and the ability to provide information about diabetes-specific associations with HRQOL, of two generic instruments, in comparison with two diabetes-specific instruments, in patients with T1DM.In a Dutch cohort of 234 patients with T1DM we longitudinally assessed HRQOL using both generic and diabetes-specific instruments. We investigated the responsiveness, the associations with diabetes-specific variables and the identification of specific patients by the instruments used.The generic RAND-36 was able to detect statistically significant and clinically relevant changes in HRQOL over time. Moreover, the RAND-36 was associated with (changes in) diabetes-specific variables. The generic and diabetes-specific instruments partly identified different patients with lowest HRQOL.The RAND-36 was highly responsive to changes in HRQOL in patients with T1DM and revealed diabetes-specific associations with HRQOL. A low correlation between the generic and diabetes-specific instruments and partly different identification of patients with lower HRQOL support the complementary use of these instruments in patients with T1DM." @default.
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- W2117843685 date "2007-03-01" @default.
- W2117843685 modified "2023-09-23" @default.
- W2117843685 title "Health related quality of life in patients with type I diabetes mellitus: generic & disease-specific measurement." @default.
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