Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117855963> ?p ?o ?g. }
- W2117855963 endingPage "9" @default.
- W2117855963 startingPage "941" @default.
- W2117855963 abstract "The p53 tumor suppressor is a transcription factor that regulates several pathways, which function collectively to maintain the integrity of the genome. Nuclear localization is critical for wild-type function. However, the signals that regulate subcellular localization of p53 have not been identified. Here, we examine the effect of ionizing radiation on the subcellular localization of p53 in two cell lines in which p53 is normally sequestered in the cytoplasm and found that ionizing radiation caused a biphasic translocation response. p53 entered the nucleus 1-2 h postirradiation (early response), subsequently emerged from the nucleus, and then again entered the nucleus 12-24 h after the cells had been irradiated (delayed response). These changes in subcellular localization could be completely blocked by the free radical scavenger, WR1065. By comparison, two DNA-damaging agents that do not generate free radicals, mitomycin C and doxorubicin, caused translocation only after 12-24 h of exposure to the drugs, and this effect could not be inhibited by WR1065. Hence, although all three DNA-damaging agents induced relocalization of p53 to the nucleus, only the translocation caused by radiation was sensitive to free radical scavenging. We suggest that the free radicals generated by ionizing radiation can signal p53 translocation to the nucleus." @default.
- W2117855963 created "2016-06-24" @default.
- W2117855963 creator A5027455966 @default.
- W2117855963 creator A5062427361 @default.
- W2117855963 creator A5066577598 @default.
- W2117855963 creator A5072467864 @default.
- W2117855963 creator A5080838230 @default.
- W2117855963 date "1997-09-01" @default.
- W2117855963 modified "2023-09-23" @default.
- W2117855963 title "Free radicals generated by ionizing radiation signal nuclear translocation of p53." @default.
- W2117855963 cites W1502887285 @default.
- W2117855963 cites W1538477674 @default.
- W2117855963 cites W1676663233 @default.
- W2117855963 cites W1861749169 @default.
- W2117855963 cites W1862654781 @default.
- W2117855963 cites W1869449658 @default.
- W2117855963 cites W1952836109 @default.
- W2117855963 cites W1978400153 @default.
- W2117855963 cites W1983045500 @default.
- W2117855963 cites W1986179131 @default.
- W2117855963 cites W1986226378 @default.
- W2117855963 cites W1995831267 @default.
- W2117855963 cites W1997646834 @default.
- W2117855963 cites W2003236156 @default.
- W2117855963 cites W2007328360 @default.
- W2117855963 cites W2014120293 @default.
- W2117855963 cites W2016254453 @default.
- W2117855963 cites W2026673148 @default.
- W2117855963 cites W2030283142 @default.
- W2117855963 cites W2037670899 @default.
- W2117855963 cites W2038890237 @default.
- W2117855963 cites W2039704215 @default.
- W2117855963 cites W2060074596 @default.
- W2117855963 cites W2060584880 @default.
- W2117855963 cites W2078731043 @default.
- W2117855963 cites W2087860209 @default.
- W2117855963 cites W2089654173 @default.
- W2117855963 cites W2090242035 @default.
- W2117855963 cites W2095711408 @default.
- W2117855963 cites W2108172661 @default.
- W2117855963 cites W2134871100 @default.
- W2117855963 cites W2149703879 @default.
- W2117855963 cites W2150990082 @default.
- W2117855963 cites W2151160119 @default.
- W2117855963 cites W2190434739 @default.
- W2117855963 cites W2233765415 @default.
- W2117855963 cites W245079648 @default.
- W2117855963 cites W2468465024 @default.
- W2117855963 cites W61326834 @default.
- W2117855963 cites W73379949 @default.
- W2117855963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9300177" @default.
- W2117855963 hasPublicationYear "1997" @default.
- W2117855963 type Work @default.
- W2117855963 sameAs 2117855963 @default.
- W2117855963 citedByCount "14" @default.
- W2117855963 countsByYear W21178559632012 @default.
- W2117855963 countsByYear W21178559632013 @default.
- W2117855963 crossrefType "journal-article" @default.
- W2117855963 hasAuthorship W2117855963A5027455966 @default.
- W2117855963 hasAuthorship W2117855963A5062427361 @default.
- W2117855963 hasAuthorship W2117855963A5066577598 @default.
- W2117855963 hasAuthorship W2117855963A5072467864 @default.
- W2117855963 hasAuthorship W2117855963A5080838230 @default.
- W2117855963 hasConcept C104317684 @default.
- W2117855963 hasConcept C111337013 @default.
- W2117855963 hasConcept C121332964 @default.
- W2117855963 hasConcept C12554922 @default.
- W2117855963 hasConcept C138626823 @default.
- W2117855963 hasConcept C143425029 @default.
- W2117855963 hasConcept C18231593 @default.
- W2117855963 hasConcept C185544564 @default.
- W2117855963 hasConcept C190062978 @default.
- W2117855963 hasConcept C2776879804 @default.
- W2117855963 hasConcept C2780114586 @default.
- W2117855963 hasConcept C2780723820 @default.
- W2117855963 hasConcept C49805395 @default.
- W2117855963 hasConcept C552990157 @default.
- W2117855963 hasConcept C55493867 @default.
- W2117855963 hasConcept C86803240 @default.
- W2117855963 hasConcept C95444343 @default.
- W2117855963 hasConceptScore W2117855963C104317684 @default.
- W2117855963 hasConceptScore W2117855963C111337013 @default.
- W2117855963 hasConceptScore W2117855963C121332964 @default.
- W2117855963 hasConceptScore W2117855963C12554922 @default.
- W2117855963 hasConceptScore W2117855963C138626823 @default.
- W2117855963 hasConceptScore W2117855963C143425029 @default.
- W2117855963 hasConceptScore W2117855963C18231593 @default.
- W2117855963 hasConceptScore W2117855963C185544564 @default.
- W2117855963 hasConceptScore W2117855963C190062978 @default.
- W2117855963 hasConceptScore W2117855963C2776879804 @default.
- W2117855963 hasConceptScore W2117855963C2780114586 @default.
- W2117855963 hasConceptScore W2117855963C2780723820 @default.
- W2117855963 hasConceptScore W2117855963C49805395 @default.
- W2117855963 hasConceptScore W2117855963C552990157 @default.
- W2117855963 hasConceptScore W2117855963C55493867 @default.
- W2117855963 hasConceptScore W2117855963C86803240 @default.
- W2117855963 hasConceptScore W2117855963C95444343 @default.
- W2117855963 hasIssue "9" @default.