FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117873437> ?p ?o ?g. }

• W2117873437 endingPage "2167" @default.
• W2117873437 startingPage "2156" @default.
• W2117873437 abstract "ABSTRACT Toxoplasma gondii transmission between intermediate hosts is dependent on the ingestion of walled cysts formed during the chronic phase of infection. Immediately following consumption, the parasite must ensure survival of the host by preventing adverse inflammatory responses and/or by limiting its own replication. Since the Toxoplasma secreted effectors rhoptry 16 kinase (ROP16) and dense granule 15 (GRA15) activate the JAK-STAT3/6 and NF-κB signaling pathways, respectively, we explored whether a particular combination of these effectors impacted intestinal inflammation and parasite survival in vivo . Here we report that expression of the STAT-activating version of ROP16 in the type II strain (strain II+ ROP16 I ) promotes host resistance to oral infection only in the context of endogenous GRA15 expression. Protection was characterized by a lower intestinal parasite burden and dampened inflammation. Host resistance to the II+ ROP16 I strain occurred independently of STAT6 and the T cell coinhibitory receptors B7-DC and B7-H1, two receptors that are upregulated by ROP16. In addition, coexpression of ROP16 and GRA15 enhanced parasite susceptibility within tumor necrosis factor alpha/gamma interferon-stimulated macrophages in a STAT3/6-independent manner. Transcriptional profiling of infected STAT3- and STAT6-deficient macrophages and parasitized Peyer's patches from mice orally challenged with strain II+ ROP16 I suggested that ROP16 activated STAT5 to modulate host gene expression. Consistent with this supposition, the ROP16 kinase induced the sustained phosphorylation and nuclear localization of STAT5 in Toxoplasma -infected cells. In summary, only the combined expression of both GRA15 and ROP16 promoted host resistance to acute oral infection, and Toxoplasma may possibly target the STAT5 signaling pathway to generate protective immunity in the gut." @default.
• W2117873437 created "2016-06-24" @default.
• W2117873437 creator A5001886862 @default.
• W2117873437 creator A5003951398 @default.
• W2117873437 creator A5010419600 @default.
• W2117873437 creator A5022185496 @default.
• W2117873437 creator A5030109235 @default.
• W2117873437 creator A5030935274 @default.
• W2117873437 creator A5035295243 @default.
• W2117873437 creator A5039005049 @default.
• W2117873437 creator A5060108187 @default.
• W2117873437 date "2013-06-01" @default.
• W2117873437 modified "2023-10-06" @default.
• W2117873437 title "Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15" @default.
• W2117873437 cites W1526901277 @default.
• W2117873437 cites W1537640495 @default.
• W2117873437 cites W1585855515 @default.
• W2117873437 cites W1592104297 @default.
• W2117873437 cites W1902639999 @default.
• W2117873437 cites W1953607369 @default.
• W2117873437 cites W1973723338 @default.
• W2117873437 cites W1981066202 @default.
• W2117873437 cites W1981958899 @default.
• W2117873437 cites W1985293294 @default.
• W2117873437 cites W1986237707 @default.
• W2117873437 cites W1989652111 @default.
• W2117873437 cites W1992834385 @default.
• W2117873437 cites W1992935467 @default.
• W2117873437 cites W1993484262 @default.
• W2117873437 cites W2004774344 @default.
• W2117873437 cites W2006213558 @default.
• W2117873437 cites W2009035135 @default.
• W2117873437 cites W2015703705 @default.
• W2117873437 cites W2016313989 @default.
• W2117873437 cites W2023957127 @default.
• W2117873437 cites W2027581425 @default.
• W2117873437 cites W2034073702 @default.
• W2117873437 cites W2038461328 @default.
• W2117873437 cites W2047084643 @default.
• W2117873437 cites W2049750787 @default.
• W2117873437 cites W2052954033 @default.
• W2117873437 cites W2055769360 @default.
• W2117873437 cites W2060267424 @default.
• W2117873437 cites W2060656527 @default.
• W2117873437 cites W2074177784 @default.
• W2117873437 cites W2080316231 @default.
• W2117873437 cites W2080944161 @default.
• W2117873437 cites W2081360252 @default.
• W2117873437 cites W2090349233 @default.
• W2117873437 cites W2098597540 @default.
• W2117873437 cites W2107879555 @default.
• W2117873437 cites W2111253543 @default.
• W2117873437 cites W2116897414 @default.
• W2117873437 cites W2117519175 @default.
• W2117873437 cites W2128627731 @default.
• W2117873437 cites W2129052947 @default.
• W2117873437 cites W2138022845 @default.
• W2117873437 cites W2138334533 @default.
• W2117873437 cites W2142939879 @default.
• W2117873437 cites W2144509281 @default.
• W2117873437 cites W2155464214 @default.
• W2117873437 cites W2157220038 @default.
• W2117873437 cites W2166029068 @default.
• W2117873437 cites W2324429495 @default.
• W2117873437 doi "https://doi.org/10.1128/iai.01185-12" @default.
• W2117873437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3676013" @default.
• W2117873437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23545295" @default.
• W2117873437 hasPublicationYear "2013" @default.
• W2117873437 type Work @default.
• W2117873437 sameAs 2117873437 @default.
• W2117873437 citedByCount "85" @default.
• W2117873437 countsByYear W21178734372014 @default.
• W2117873437 countsByYear W21178734372015 @default.
• W2117873437 countsByYear W21178734372016 @default.
• W2117873437 countsByYear W21178734372017 @default.
• W2117873437 countsByYear W21178734372018 @default.
• W2117873437 countsByYear W21178734372019 @default.
• W2117873437 countsByYear W21178734372020 @default.
• W2117873437 countsByYear W21178734372021 @default.
• W2117873437 countsByYear W21178734372022 @default.
• W2117873437 countsByYear W21178734372023 @default.
• W2117873437 crossrefType "journal-article" @default.
• W2117873437 hasAuthorship W2117873437A5001886862 @default.
• W2117873437 hasAuthorship W2117873437A5003951398 @default.
• W2117873437 hasAuthorship W2117873437A5010419600 @default.
• W2117873437 hasAuthorship W2117873437A5022185496 @default.
• W2117873437 hasAuthorship W2117873437A5030109235 @default.
• W2117873437 hasAuthorship W2117873437A5030935274 @default.
• W2117873437 hasAuthorship W2117873437A5035295243 @default.
• W2117873437 hasAuthorship W2117873437A5039005049 @default.
• W2117873437 hasAuthorship W2117873437A5060108187 @default.
• W2117873437 hasBestOaLocation W21178734371 @default.
• W2117873437 hasConcept C159654299 @default.
• W2117873437 hasConcept C17991360 @default.
• W2117873437 hasConcept C203014093 @default.
• W2117873437 hasConcept C2776914184 @default.
• W2117873437 hasConcept C2778128430 @default.
• W2117873437 hasConcept C2778923194 @default.

• next