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- W2117882587 startingPage "275" @default.
- W2117882587 abstract "Chemotherapy plays an indispensable role in the management of leukemia. However, resistance development and lack of selectivity are major drawbacks. Unfortunate side effects of chemotherapy create a continuous demand for developing other novel strategies for treatment. Epigenetic modulation of gene expression is one of the emerging and promising strategies that has demonstrated successful clinical outcome in acute myeloid leukemis (AML). However, the exact molecular mechanism of action of epigenetic modifiers remains unclear. Ongoing clinical trials are attempting to identify the possible candidate genes that upon re-expression can induce remission and cure in patients. Interestingly, epigenetic modifiers exhibit other pharmacological effects not related to gene expression modulation, including generation of reactive oxygen species and DNA damage induction. It appears that epigenetic therapy is having a promising impact in myelodysplatic syndrome (MDS) and leukemia, but exactly how these epigenetic modifiers achieve clinical responses remains to be elucidated." @default.
- W2117882587 created "2016-06-24" @default.
- W2117882587 creator A5016810759 @default.
- W2117882587 creator A5047899936 @default.
- W2117882587 creator A5052920087 @default.
- W2117882587 date "2007-01-01" @default.
- W2117882587 modified "2023-09-27" @default.
- W2117882587 title "Modulating Gene Expression as a Therapeutic Approach in the Treatment of AML" @default.
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- W2117882587 doi "https://doi.org/10.1007/978-1-59745-322-6_13" @default.