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• W2117886520 startingPage "3279" @default.
• W2117886520 abstract "ABSTRACT The apicomplexan parasite Toxoplasma gondii can cause severe disease in immunocompromised individuals. Previous studies in mice have focused largely on CD8 + T cells, and the role of CD4 T cells is relatively unexplored. Here, we show that immunization of the C57BL/6 strain of mice, in which the immunodominant CD8 T cell response to the parasite dense-granule protein GRA6 cannot be generated, leads to a prominent CD4 T cell response. To identify the CD4 T cell-stimulating antigens, we generated a T. gondii -specific, lacZ -inducible, CD4 T cell hybridoma and used it as a probe to screen a T. gondii cDNA library. We isolated a cDNA encoding a protein of unknown function that we call CD4Ag28m and identified the minimal peptide, AS15, which was presented by major histocompatibility complex (MHC) class II molecules to the CD4 T cells. Immunization of mice with the AS15 peptide provided significant protection against subsequent parasite challenge, resulting in a lower parasite burden in the brain. Our findings identify the first CD4 T cell-stimulating peptide that can confer protection against toxoplasmosis and provide an important tool for the study of CD4 T cell responses and the design of effective vaccines against the parasite." @default.
• W2117886520 created "2016-06-24" @default.
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• W2117886520 date "2012-09-01" @default.
• W2117886520 modified "2023-10-10" @default.
• W2117886520 title "The Toxoplasma gondii Peptide AS15 Elicits CD4 T Cells That Can Control Parasite Burden" @default.
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• W2117886520 doi "https://doi.org/10.1128/iai.00425-12" @default.
• W2117886520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418726" @default.
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