FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117917811> ?p ?o ?g. }

• W2117917811 endingPage "ORSF68" @default.
• W2117917811 startingPage "ORSF68" @default.
• W2117917811 abstract "Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AMD (generally characterized as either “wet” neovascular AMD, “dry” atrophic AMD or both), in which central vision is severely compromised or lost. Until recently, there have been no therapies available to treat the disorder(s). Now, the most common wet form of late-stage AMD, choroidal neovascularization, generally responds to treatment with anti–vascular endothelial growth factor therapies. Nevertheless, there are no current therapies to restore lost vision in eyes with advanced atrophic AMD. Oral supplementation with the Age-Related Eye Disease Study (AREDS) or AREDS2 formulation (antioxidant vitamins C and E, lutein, zeaxanthin, and zinc) has been shown to reduce the risk of progression to advanced AMD, although the impact was in neovascular rather than atrophic AMD. Recent findings, however, have demonstrated several features of early AMD that are likely to be druggable targets for treatment. Studies have established that much of the genetic risk for AMD is associated with complement genes. Consequently, several complement-based therapeutic treatment approaches are being pursued. Potential treatment strategies against AMD deposit formation and protein and/or lipid deposition will be discussed, including anti-amyloid therapies. In addition, the role of autophagy in AMD and prevention of oxidative stress through modulation of the antioxidant system will be explored. Finally, the success of these new therapies in clinical trials and beyond relies on early detection, disease typing, and predicting disease progression, areas that are currently being rapidly transformed by improving imaging modalities and functional assays." @default.
• W2117917811 created "2016-06-24" @default.
• W2117917811 creator A5023246096 @default.
• W2117917811 creator A5023633559 @default.
• W2117917811 creator A5051860617 @default.
• W2117917811 creator A5090512897 @default.
• W2117917811 date "2013-12-13" @default.
• W2117917811 modified "2023-10-16" @default.
• W2117917811 title "Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging" @default.
• W2117917811 cites W1491374817 @default.
• W2117917811 cites W1507476909 @default.
• W2117917811 cites W1521025961 @default.
• W2117917811 cites W1532387977 @default.
• W2117917811 cites W1547554564 @default.
• W2117917811 cites W1563349777 @default.
• W2117917811 cites W159419684 @default.
• W2117917811 cites W1665485129 @default.
• W2117917811 cites W1776177507 @default.
• W2117917811 cites W180947891 @default.
• W2117917811 cites W1842277521 @default.
• W2117917811 cites W1883306593 @default.
• W2117917811 cites W1898328784 @default.
• W2117917811 cites W1945852795 @default.
• W2117917811 cites W1964730685 @default.
• W2117917811 cites W1965083039 @default.
• W2117917811 cites W1965404473 @default.
• W2117917811 cites W1965470471 @default.
• W2117917811 cites W1968788272 @default.
• W2117917811 cites W1969157499 @default.
• W2117917811 cites W1969664442 @default.
• W2117917811 cites W1970371629 @default.
• W2117917811 cites W1970714860 @default.
• W2117917811 cites W1971967380 @default.
• W2117917811 cites W1972229580 @default.
• W2117917811 cites W1972642682 @default.
• W2117917811 cites W1974007609 @default.
• W2117917811 cites W1974378004 @default.
• W2117917811 cites W1974632887 @default.
• W2117917811 cites W1974943838 @default.
• W2117917811 cites W1975348685 @default.
• W2117917811 cites W1978438207 @default.
• W2117917811 cites W1979854281 @default.
• W2117917811 cites W1980344266 @default.
• W2117917811 cites W1981111037 @default.
• W2117917811 cites W1981344509 @default.
• W2117917811 cites W1987162905 @default.
• W2117917811 cites W1987184171 @default.
• W2117917811 cites W1989558725 @default.
• W2117917811 cites W1989747234 @default.
• W2117917811 cites W1989763172 @default.
• W2117917811 cites W1992430680 @default.
• W2117917811 cites W1993096645 @default.
• W2117917811 cites W1993836555 @default.
• W2117917811 cites W1993996853 @default.
• W2117917811 cites W1994071473 @default.
• W2117917811 cites W1994554610 @default.
• W2117917811 cites W1995006312 @default.
• W2117917811 cites W1995693747 @default.
• W2117917811 cites W1997288094 @default.
• W2117917811 cites W2000399151 @default.
• W2117917811 cites W2000696816 @default.
• W2117917811 cites W2001080026 @default.
• W2117917811 cites W2001720244 @default.
• W2117917811 cites W2002437061 @default.
• W2117917811 cites W2002712265 @default.
• W2117917811 cites W2002870197 @default.
• W2117917811 cites W2003101845 @default.
• W2117917811 cites W2003674452 @default.
• W2117917811 cites W2003797682 @default.
• W2117917811 cites W2005487633 @default.
• W2117917811 cites W2006242015 @default.
• W2117917811 cites W2006590663 @default.
• W2117917811 cites W2007668953 @default.
• W2117917811 cites W2011237852 @default.
• W2117917811 cites W2012796647 @default.
• W2117917811 cites W2012862669 @default.
• W2117917811 cites W2013673496 @default.
• W2117917811 cites W2016520383 @default.
• W2117917811 cites W2018719587 @default.
• W2117917811 cites W2021229920 @default.
• W2117917811 cites W2021724765 @default.
• W2117917811 cites W2022799658 @default.
• W2117917811 cites W2024116613 @default.
• W2117917811 cites W2024741954 @default.
• W2117917811 cites W2027606067 @default.
• W2117917811 cites W2027707278 @default.
• W2117917811 cites W2030628584 @default.
• W2117917811 cites W2033662964 @default.
• W2117917811 cites W2034347345 @default.
• W2117917811 cites W2034981780 @default.
• W2117917811 cites W2036317458 @default.
• W2117917811 cites W2037272767 @default.
• W2117917811 cites W2039002855 @default.
• W2117917811 cites W2041021406 @default.
• W2117917811 cites W2043975730 @default.
• W2117917811 cites W2045003373 @default.
• W2117917811 cites W2049537377 @default.
• W2117917811 cites W2050534471 @default.

• next