FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117923185> ?p ?o ?g. }

• W2117923185 endingPage "4516" @default.
• W2117923185 startingPage "4507" @default.
• W2117923185 abstract "The RET receptor tyrosine kinase plays a critical role in the development of the enteric nervous system (ENS) and the kidney. Upon glial-cell-line-derived neurotrophic factor (GDNF) stimulation, RET can activate a variety of intracellular signals, including the Ras/mitogen-activated protein kinase, phosphatidylinositol 3-kinase(PI3K)/AKT, and RAC1/JUN NH2-terminal kinase (JNK) pathways. We recently demonstrated that the RAC1/JNK pathway is regulated by serine phosphorylation at the juxtamembrane region of RET in a cAMP-dependent manner. To determine the importance of cAMP-dependent modification of the RET signal in vivo, we generated mutant mice in which serine residue 697, a putative protein kinase A (PKA) phosphorylation site, was replaced with alanine(designated S697A mice). Homozygous S697A mutant mice lacked the ENS in the distal colon, resulting from a migration defect of enteric neural crest cells(ENCCs). In vitro organ culture showed an impaired chemoattractant response of the mutant ENCCs to GDNF. JNK activation by GDNF but not ERK, AKT and SRC activation was markedly reduced in neurons derived from the mutant mice. The JNK inhibitor SP600125 and the PKA inhibitor KT5720 suppressed migration of the ENCCs in cultured guts from wild-type mice to comparable degrees. Thus,these findings indicated that cAMP-dependent modification of RET function regulates the JNK signaling responsible for proper migration of the ENCCs in the developing gut." @default.
• W2117923185 created "2016-06-24" @default.
• W2117923185 creator A5002266768 @default.
• W2117923185 creator A5007226245 @default.
• W2117923185 creator A5012592108 @default.
• W2117923185 creator A5028812875 @default.
• W2117923185 creator A5030883161 @default.
• W2117923185 creator A5044164305 @default.
• W2117923185 creator A5048038268 @default.
• W2117923185 date "2006-11-15" @default.
• W2117923185 modified "2023-09-30" @default.
• W2117923185 title "Targeted mutation of serine 697 in the<i>Ret</i>tyrosine kinase causes migration defect of enteric neural crest cells" @default.
• W2117923185 cites W1516316082 @default.
• W2117923185 cites W1578346366 @default.
• W2117923185 cites W1828734482 @default.
• W2117923185 cites W1965903181 @default.
• W2117923185 cites W1971208141 @default.
• W2117923185 cites W1971238657 @default.
• W2117923185 cites W1980815930 @default.
• W2117923185 cites W1981173539 @default.
• W2117923185 cites W1982144815 @default.
• W2117923185 cites W1983436563 @default.
• W2117923185 cites W1986163885 @default.
• W2117923185 cites W1987566228 @default.
• W2117923185 cites W1989343086 @default.
• W2117923185 cites W1993326304 @default.
• W2117923185 cites W1997864509 @default.
• W2117923185 cites W1999693507 @default.
• W2117923185 cites W2013024179 @default.
• W2117923185 cites W2014078232 @default.
• W2117923185 cites W2015127215 @default.
• W2117923185 cites W2027322371 @default.
• W2117923185 cites W2028093783 @default.
• W2117923185 cites W2030996806 @default.
• W2117923185 cites W2036169332 @default.
• W2117923185 cites W2038055852 @default.
• W2117923185 cites W2038754749 @default.
• W2117923185 cites W2040196938 @default.
• W2117923185 cites W2043072647 @default.
• W2117923185 cites W2049918202 @default.
• W2117923185 cites W2050904439 @default.
• W2117923185 cites W2051945956 @default.
• W2117923185 cites W2051998916 @default.
• W2117923185 cites W2057547625 @default.
• W2117923185 cites W2060630008 @default.
• W2117923185 cites W2066150663 @default.
• W2117923185 cites W2068634777 @default.
• W2117923185 cites W2073412279 @default.
• W2117923185 cites W2079356305 @default.
• W2117923185 cites W2082584428 @default.
• W2117923185 cites W2083248512 @default.
• W2117923185 cites W2088699600 @default.
• W2117923185 cites W2094389804 @default.
• W2117923185 cites W2094772268 @default.
• W2117923185 cites W2104281780 @default.
• W2117923185 cites W2109067831 @default.
• W2117923185 cites W2121038814 @default.
• W2117923185 cites W2130731229 @default.
• W2117923185 cites W2135776211 @default.
• W2117923185 cites W2140917240 @default.
• W2117923185 cites W2150094887 @default.
• W2117923185 cites W2151646137 @default.
• W2117923185 cites W2154500684 @default.
• W2117923185 cites W2158193201 @default.
• W2117923185 cites W2163107282 @default.
• W2117923185 cites W2168345543 @default.
• W2117923185 cites W2169301451 @default.
• W2117923185 cites W2316331333 @default.
• W2117923185 doi "https://doi.org/10.1242/dev.02616" @default.
• W2117923185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17050626" @default.
• W2117923185 hasPublicationYear "2006" @default.
• W2117923185 type Work @default.
• W2117923185 sameAs 2117923185 @default.
• W2117923185 citedByCount "92" @default.
• W2117923185 countsByYear W21179231852012 @default.
• W2117923185 countsByYear W21179231852013 @default.
• W2117923185 countsByYear W21179231852014 @default.
• W2117923185 countsByYear W21179231852015 @default.
• W2117923185 countsByYear W21179231852016 @default.
• W2117923185 countsByYear W21179231852017 @default.
• W2117923185 countsByYear W21179231852018 @default.
• W2117923185 countsByYear W21179231852019 @default.
• W2117923185 countsByYear W21179231852020 @default.
• W2117923185 countsByYear W21179231852021 @default.
• W2117923185 countsByYear W21179231852022 @default.
• W2117923185 countsByYear W21179231852023 @default.
• W2117923185 crossrefType "journal-article" @default.
• W2117923185 hasAuthorship W2117923185A5002266768 @default.
• W2117923185 hasAuthorship W2117923185A5007226245 @default.
• W2117923185 hasAuthorship W2117923185A5012592108 @default.
• W2117923185 hasAuthorship W2117923185A5028812875 @default.
• W2117923185 hasAuthorship W2117923185A5030883161 @default.
• W2117923185 hasAuthorship W2117923185A5044164305 @default.
• W2117923185 hasAuthorship W2117923185A5048038268 @default.
• W2117923185 hasBestOaLocation W21179231851 @default.
• W2117923185 hasConcept C101544691 @default.
• W2117923185 hasConcept C108636557 @default.
• W2117923185 hasConcept C11960822 @default.

• next