Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117932908> ?p ?o ?g. }
- W2117932908 endingPage "2820" @default.
- W2117932908 startingPage "2813" @default.
- W2117932908 abstract "Leptin may rapidly inhibit food intake by altering the secretion of hypothalamic neuropeptides such as neuropeptide Y (NPY), a stimulator of food intake, and/or corticotropin-releasing hormone (CRH), an inhibitor of food intake. We measured concentrations of NPY and CRH in specific hypothalamic regions [i.e., arcuate nucleus (ARC), paraventricular nucleus (PVN), ventromedial nucleus and dorsomedial nucleus] of 7- to 8-wk-old lean and ob/ob mice at 1 or 3 h after intracerebroventricular leptin administration. No rapid-onset effects of leptin on hypothalamic NPY or CRH concentrations were observed in intact mice. The addition of leptin to hypothalamic preparations from intact mice also did not alter NPY or CRH secretion. Glucocorticoids may oppose leptin actions. Consistent with this, leptin administration to adrenalectomized mice markedly reduced CRH concentrations in the ARC within 3 h after injection. This rapid reduction in CRH concentration in the ARC after leptin administration is more likely due to stimulated CRH release from this region than to decreased synthesis/transport from the PVN because leptin stimulates CRH synthesis in the PVN. Within 20 min after exposure to leptin, NPY secretion from hypothalamic preparations obtained from adrenalectomized mice was lowered by 27% and CRH secretion was elevated by 51%. The current study demonstrates that leptin rapidly influences the secretion of hypothalamic NPY and CRH and that these actions of leptin within the hypothalamus are restrained by the presence of endogenous corticosterone." @default.
- W2117932908 created "2016-06-24" @default.
- W2117932908 creator A5037639292 @default.
- W2117932908 creator A5050410814 @default.
- W2117932908 creator A5055731449 @default.
- W2117932908 creator A5087700355 @default.
- W2117932908 date "2000-11-01" @default.
- W2117932908 modified "2023-10-13" @default.
- W2117932908 title "Leptin Rapidly Inhibits Hypothalamic Neuropeptide Y Secretion and Stimulates Corticotropin-Releasing Hormone Secretion in Adrenalectomized Mice" @default.
- W2117932908 cites W1623365227 @default.
- W2117932908 cites W1967501438 @default.
- W2117932908 cites W1968666103 @default.
- W2117932908 cites W1974760551 @default.
- W2117932908 cites W1974885644 @default.
- W2117932908 cites W1978638225 @default.
- W2117932908 cites W1983372510 @default.
- W2117932908 cites W1987289944 @default.
- W2117932908 cites W1987376546 @default.
- W2117932908 cites W1988415053 @default.
- W2117932908 cites W1993021677 @default.
- W2117932908 cites W1999566361 @default.
- W2117932908 cites W2001660140 @default.
- W2117932908 cites W2010342389 @default.
- W2117932908 cites W2012805490 @default.
- W2117932908 cites W2013002120 @default.
- W2117932908 cites W2013583119 @default.
- W2117932908 cites W2014163208 @default.
- W2117932908 cites W2026677009 @default.
- W2117932908 cites W2034116199 @default.
- W2117932908 cites W2034693412 @default.
- W2117932908 cites W2038406912 @default.
- W2117932908 cites W2040965413 @default.
- W2117932908 cites W2051149370 @default.
- W2117932908 cites W2056432051 @default.
- W2117932908 cites W2058779049 @default.
- W2117932908 cites W2059035261 @default.
- W2117932908 cites W2061430646 @default.
- W2117932908 cites W2070074337 @default.
- W2117932908 cites W2075019242 @default.
- W2117932908 cites W2077674418 @default.
- W2117932908 cites W2092326011 @default.
- W2117932908 cites W2096679336 @default.
- W2117932908 cites W2097378006 @default.
- W2117932908 cites W2098627686 @default.
- W2117932908 cites W2111232488 @default.
- W2117932908 cites W2121594859 @default.
- W2117932908 cites W2144585690 @default.
- W2117932908 cites W2151083080 @default.
- W2117932908 cites W4230735296 @default.
- W2117932908 doi "https://doi.org/10.1093/jn/130.11.2813" @default.
- W2117932908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11053526" @default.
- W2117932908 hasPublicationYear "2000" @default.
- W2117932908 type Work @default.
- W2117932908 sameAs 2117932908 @default.
- W2117932908 citedByCount "68" @default.
- W2117932908 countsByYear W21179329082012 @default.
- W2117932908 countsByYear W21179329082013 @default.
- W2117932908 countsByYear W21179329082014 @default.
- W2117932908 countsByYear W21179329082015 @default.
- W2117932908 countsByYear W21179329082017 @default.
- W2117932908 countsByYear W21179329082018 @default.
- W2117932908 countsByYear W21179329082019 @default.
- W2117932908 countsByYear W21179329082020 @default.
- W2117932908 countsByYear W21179329082021 @default.
- W2117932908 countsByYear W21179329082022 @default.
- W2117932908 countsByYear W21179329082023 @default.
- W2117932908 crossrefType "journal-article" @default.
- W2117932908 hasAuthorship W2117932908A5037639292 @default.
- W2117932908 hasAuthorship W2117932908A5050410814 @default.
- W2117932908 hasAuthorship W2117932908A5055731449 @default.
- W2117932908 hasAuthorship W2117932908A5087700355 @default.
- W2117932908 hasBestOaLocation W21179329081 @default.
- W2117932908 hasConcept C118303440 @default.
- W2117932908 hasConcept C126322002 @default.
- W2117932908 hasConcept C134018914 @default.
- W2117932908 hasConcept C170493617 @default.
- W2117932908 hasConcept C185592680 @default.
- W2117932908 hasConcept C2524010 @default.
- W2117932908 hasConcept C2777003273 @default.
- W2117932908 hasConcept C2778458369 @default.
- W2117932908 hasConcept C2778458438 @default.
- W2117932908 hasConcept C2780352252 @default.
- W2117932908 hasConcept C2780613262 @default.
- W2117932908 hasConcept C33923547 @default.
- W2117932908 hasConcept C49039625 @default.
- W2117932908 hasConcept C511355011 @default.
- W2117932908 hasConcept C71315377 @default.
- W2117932908 hasConcept C71924100 @default.
- W2117932908 hasConcept C83415579 @default.
- W2117932908 hasConcept C86803240 @default.
- W2117932908 hasConcept C93984277 @default.
- W2117932908 hasConceptScore W2117932908C118303440 @default.
- W2117932908 hasConceptScore W2117932908C126322002 @default.
- W2117932908 hasConceptScore W2117932908C134018914 @default.
- W2117932908 hasConceptScore W2117932908C170493617 @default.
- W2117932908 hasConceptScore W2117932908C185592680 @default.
- W2117932908 hasConceptScore W2117932908C2524010 @default.
- W2117932908 hasConceptScore W2117932908C2777003273 @default.