FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117942006> ?p ?o ?g. }

• W2117942006 endingPage "257" @default.
• W2117942006 startingPage "245" @default.
• W2117942006 abstract "Sarcomere formation has been shown to be deficient in the myocardium of axolotl embryos homozygous for the recessive cardiac lethal gene c. We examined the developing hearts of normal and cardiac mutant embryos from tailbud stage 33 to posthatching stage 43 by scanning electron microscopy in order to determine whether that deficiency has any effect on heart morphogenesis. Specifically, we investigated the relationships of myocardial cells during the formation of the heart tube (stage 33), the initiation of dextral looping (stages 34–36), and the subsequent flexure of the elongating heart (stages 38–43). In addition, we compared the morphogenetic events in the axolotl to the published accounts of comparable stages in the chick embryo. In the axolotl (stage 33), changes in cell shape and orientation accompany the closure of the myocardial trough to form the tubular heart. The ventral mesocardium persists longer in the axolotl embryo than in the chick and appears to contribute to the asymmetry of dextral looping (stages 34–36) in two ways. First, as a persisting structure it places constraints on the simple elongation of the heart tube and the ability of the heart to bend. Second, after it is resorbed, the ventral myocardial cells that contributed to it are identifiable by their orientation, which is orthogonal to adjacent cells: a potential source of shearing effects. Cardiac lethal mutant embryos behave identically during these events, indicating that functional sarcomeres are not necessary to these processes. The absence of dynamic apical myocardial membrane changes, characteristic of the chick embryo (Hamburger and Hamilton stages 9–11), suggests that sudden hydration of the cardiac jelly is less likely to be a major factor in axolotl cardiac morphogenesis. Subsequent flexure (stages 38–43) of the axolotl heart is the same in normal and cardiac lethal mutant embryos as the myocardial tube lengthens within the confines of a pericardial cavity of fixed length. However, the cardiac mutant begins to exhibit abnormalities at this time. The lack of trabeculation (normally beginning at stage 37) in the mutant ventricle is evident at the same time as an increase in myocardial surface area, manifest in extra bends of the heart tube at stage 39. Nonbeating mutant hearts (stage 41) have an abnormally large diameter in the atrioventricular region, possibly the result of the accumulation of ascites fluid. In addition, mutant myocardial cells have a larger apical surface area compared to normals." @default.
• W2117942006 created "2016-06-24" @default.
• W2117942006 creator A5004757150 @default.
• W2117942006 creator A5034291111 @default.
• W2117942006 date "1988-11-01" @default.
• W2117942006 modified "2023-10-17" @default.
• W2117942006 title "Myocardial cell relationships during morphogenesis in normal and cardiac lethal mutant axolotls,Ambystoma mexicanum" @default.
• W2117942006 cites W1982726291 @default.
• W2117942006 cites W1987989974 @default.
• W2117942006 cites W1989717646 @default.
• W2117942006 cites W2000461820 @default.
• W2117942006 cites W2010582588 @default.
• W2117942006 cites W2012654459 @default.
• W2117942006 cites W2024563235 @default.
• W2117942006 cites W2033583628 @default.
• W2117942006 cites W2034854374 @default.
• W2117942006 cites W2039704343 @default.
• W2117942006 cites W2041182781 @default.
• W2117942006 cites W2055033181 @default.
• W2117942006 cites W2055646157 @default.
• W2117942006 cites W2059581749 @default.
• W2117942006 cites W2063491704 @default.
• W2117942006 cites W2085113659 @default.
• W2117942006 cites W2085680023 @default.
• W2117942006 cites W2122192059 @default.
• W2117942006 cites W2127537051 @default.
• W2117942006 cites W2147081672 @default.
• W2117942006 cites W2422024227 @default.
• W2117942006 doi "https://doi.org/10.1002/aja.1001830307" @default.
• W2117942006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3213830" @default.
• W2117942006 hasPublicationYear "1988" @default.
• W2117942006 type Work @default.
• W2117942006 sameAs 2117942006 @default.
• W2117942006 citedByCount "13" @default.
• W2117942006 countsByYear W21179420062012 @default.
• W2117942006 countsByYear W21179420062014 @default.
• W2117942006 countsByYear W21179420062019 @default.
• W2117942006 countsByYear W21179420062021 @default.
• W2117942006 crossrefType "journal-article" @default.
• W2117942006 hasAuthorship W2117942006A5004757150 @default.
• W2117942006 hasAuthorship W2117942006A5034291111 @default.
• W2117942006 hasConcept C104317684 @default.
• W2117942006 hasConcept C105702510 @default.
• W2117942006 hasConcept C126322002 @default.
• W2117942006 hasConcept C145103041 @default.
• W2117942006 hasConcept C171056886 @default.
• W2117942006 hasConcept C196843134 @default.
• W2117942006 hasConcept C207200792 @default.
• W2117942006 hasConcept C2779617070 @default.
• W2117942006 hasConcept C2779945282 @default.
• W2117942006 hasConcept C2908669727 @default.
• W2117942006 hasConcept C40692019 @default.
• W2117942006 hasConcept C54355233 @default.
• W2117942006 hasConcept C62425271 @default.
• W2117942006 hasConcept C68731436 @default.
• W2117942006 hasConcept C71924100 @default.
• W2117942006 hasConcept C86803240 @default.
• W2117942006 hasConcept C95444343 @default.
• W2117942006 hasConceptScore W2117942006C104317684 @default.
• W2117942006 hasConceptScore W2117942006C105702510 @default.
• W2117942006 hasConceptScore W2117942006C126322002 @default.
• W2117942006 hasConceptScore W2117942006C145103041 @default.
• W2117942006 hasConceptScore W2117942006C171056886 @default.
• W2117942006 hasConceptScore W2117942006C196843134 @default.
• W2117942006 hasConceptScore W2117942006C207200792 @default.
• W2117942006 hasConceptScore W2117942006C2779617070 @default.
• W2117942006 hasConceptScore W2117942006C2779945282 @default.
• W2117942006 hasConceptScore W2117942006C2908669727 @default.
• W2117942006 hasConceptScore W2117942006C40692019 @default.
• W2117942006 hasConceptScore W2117942006C54355233 @default.
• W2117942006 hasConceptScore W2117942006C62425271 @default.
• W2117942006 hasConceptScore W2117942006C68731436 @default.
• W2117942006 hasConceptScore W2117942006C71924100 @default.
• W2117942006 hasConceptScore W2117942006C86803240 @default.
• W2117942006 hasConceptScore W2117942006C95444343 @default.
• W2117942006 hasIssue "3" @default.
• W2117942006 hasLocation W21179420061 @default.
• W2117942006 hasLocation W21179420062 @default.
• W2117942006 hasOpenAccess W2117942006 @default.
• W2117942006 hasPrimaryLocation W21179420061 @default.
• W2117942006 hasRelatedWork W1981195568 @default.
• W2117942006 hasRelatedWork W2050899987 @default.
• W2117942006 hasRelatedWork W2098209017 @default.
• W2117942006 hasRelatedWork W2117942006 @default.
• W2117942006 hasRelatedWork W2460863110 @default.
• W2117942006 hasRelatedWork W263444227 @default.
• W2117942006 hasRelatedWork W3037105629 @default.
• W2117942006 hasRelatedWork W3194180904 @default.
• W2117942006 hasRelatedWork W4290344290 @default.
• W2117942006 hasRelatedWork W818088704 @default.
• W2117942006 hasVolume "183" @default.
• W2117942006 isParatext "false" @default.
• W2117942006 isRetracted "false" @default.
• W2117942006 magId "2117942006" @default.
• W2117942006 workType "article" @default.