Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117942378> ?p ?o ?g. }
- W2117942378 endingPage "417" @default.
- W2117942378 startingPage "407" @default.
- W2117942378 abstract "Abstract Basal cell carcinoma (BCC) is the most common human cancer. We have demonstrated previously that topical application of the retinoid prodrug tazarotene profoundly inhibits murine BCC carcinogenesis via retinoic acid receptor γ–mediated regulation of tumor cell transcription. Because topical retinoids can cause adverse cutaneous effects and because tumors can develop resistance to retinoids, we have investigated mechanisms downstream of tazarotene's antitumor effect in this model. Specifically we have used (i) global expression profiling to identify and (ii) functional cell-based assays to validate the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway as a downstream target pathway of tazarotene's action. Crucially, we have demonstrated that pharmacologic inhibition of this downstream pathway profoundly reduces murine BCC cell proliferation and tumorigenesis both in vitro and in vivo. These data identify PI3K/AKT/mTOR signaling as a highly attractive target for BCC chemoprevention and indicate more generally that this pathway may be, in some contexts, an important mediator of retinoid anticancer effects. Cancer Prev Res; 7(4); 407–17. ©2014 AACR." @default.
- W2117942378 created "2016-06-24" @default.
- W2117942378 creator A5031964615 @default.
- W2117942378 creator A5041671653 @default.
- W2117942378 creator A5059783962 @default.
- W2117942378 creator A5059902188 @default.
- W2117942378 creator A5071785832 @default.
- W2117942378 creator A5085985235 @default.
- W2117942378 creator A5090973835 @default.
- W2117942378 date "2014-04-01" @default.
- W2117942378 modified "2023-10-16" @default.
- W2117942378 title "PI3K-AKT Signaling Is a Downstream Effector of Retinoid Prevention of Murine Basal Cell Carcinogenesis" @default.
- W2117942378 cites W1965500674 @default.
- W2117942378 cites W1965568759 @default.
- W2117942378 cites W1970960957 @default.
- W2117942378 cites W1972517554 @default.
- W2117942378 cites W1977267072 @default.
- W2117942378 cites W1984033355 @default.
- W2117942378 cites W1987642183 @default.
- W2117942378 cites W1990453562 @default.
- W2117942378 cites W2001155940 @default.
- W2117942378 cites W2007466152 @default.
- W2117942378 cites W2007600985 @default.
- W2117942378 cites W2012242068 @default.
- W2117942378 cites W2013585067 @default.
- W2117942378 cites W2022425019 @default.
- W2117942378 cites W2026237709 @default.
- W2117942378 cites W2029754521 @default.
- W2117942378 cites W2041414354 @default.
- W2117942378 cites W2046081435 @default.
- W2117942378 cites W2051719153 @default.
- W2117942378 cites W2054657634 @default.
- W2117942378 cites W2059203391 @default.
- W2117942378 cites W2060156100 @default.
- W2117942378 cites W2061574261 @default.
- W2117942378 cites W2070942270 @default.
- W2117942378 cites W2088811912 @default.
- W2117942378 cites W2090176557 @default.
- W2117942378 cites W2100868792 @default.
- W2117942378 cites W2101476206 @default.
- W2117942378 cites W2110095356 @default.
- W2117942378 cites W2111685017 @default.
- W2117942378 cites W2120865735 @default.
- W2117942378 cites W2124009292 @default.
- W2117942378 cites W2134435180 @default.
- W2117942378 cites W2149450040 @default.
- W2117942378 cites W2153582124 @default.
- W2117942378 cites W2159566901 @default.
- W2117942378 cites W2161102475 @default.
- W2117942378 cites W2164784911 @default.
- W2117942378 cites W2166581740 @default.
- W2117942378 doi "https://doi.org/10.1158/1940-6207.capr-13-0304" @default.
- W2117942378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4046911" @default.
- W2117942378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24449057" @default.
- W2117942378 hasPublicationYear "2014" @default.
- W2117942378 type Work @default.
- W2117942378 sameAs 2117942378 @default.
- W2117942378 citedByCount "14" @default.
- W2117942378 countsByYear W21179423782014 @default.
- W2117942378 countsByYear W21179423782015 @default.
- W2117942378 countsByYear W21179423782016 @default.
- W2117942378 countsByYear W21179423782017 @default.
- W2117942378 countsByYear W21179423782019 @default.
- W2117942378 countsByYear W21179423782021 @default.
- W2117942378 countsByYear W21179423782022 @default.
- W2117942378 crossrefType "journal-article" @default.
- W2117942378 hasAuthorship W2117942378A5031964615 @default.
- W2117942378 hasAuthorship W2117942378A5041671653 @default.
- W2117942378 hasAuthorship W2117942378A5059783962 @default.
- W2117942378 hasAuthorship W2117942378A5059902188 @default.
- W2117942378 hasAuthorship W2117942378A5071785832 @default.
- W2117942378 hasAuthorship W2117942378A5085985235 @default.
- W2117942378 hasAuthorship W2117942378A5090973835 @default.
- W2117942378 hasBestOaLocation W21179423781 @default.
- W2117942378 hasConcept C121608353 @default.
- W2117942378 hasConcept C185592680 @default.
- W2117942378 hasConcept C2775954498 @default.
- W2117942378 hasConcept C2781121885 @default.
- W2117942378 hasConcept C502942594 @default.
- W2117942378 hasConcept C54355233 @default.
- W2117942378 hasConcept C55493867 @default.
- W2117942378 hasConcept C555283112 @default.
- W2117942378 hasConcept C62112901 @default.
- W2117942378 hasConcept C62478195 @default.
- W2117942378 hasConcept C75217442 @default.
- W2117942378 hasConcept C81885089 @default.
- W2117942378 hasConcept C86554907 @default.
- W2117942378 hasConcept C86803240 @default.
- W2117942378 hasConcept C95444343 @default.
- W2117942378 hasConceptScore W2117942378C121608353 @default.
- W2117942378 hasConceptScore W2117942378C185592680 @default.
- W2117942378 hasConceptScore W2117942378C2775954498 @default.
- W2117942378 hasConceptScore W2117942378C2781121885 @default.
- W2117942378 hasConceptScore W2117942378C502942594 @default.
- W2117942378 hasConceptScore W2117942378C54355233 @default.
- W2117942378 hasConceptScore W2117942378C55493867 @default.
- W2117942378 hasConceptScore W2117942378C555283112 @default.
- W2117942378 hasConceptScore W2117942378C62112901 @default.