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- W2117948488 abstract "Total sleep time, sleep difficulty (time spent awake and moving during sleep), REM latency (time to first REM period), number of REM periods, and time spent in sleep stages, REM,I, II, III and IV, were measured in four patients with growth hormone (GH) deficiency before and after GH therapy. Three patients adapted for 2 or more nights prior to the study and each patient had 2 or more studies. One patient had one study after GH. The percentage of time spent in stage II sleep increased in three patients while in the fourth patient it did not change. The mean percentages (minutes) of stage II sleep were 40.4% (223 min) and 43.2% (218 min) before and after respectively. The amount of time spent in slow-wave (III/IV) sleep was found to decrease in three patients. The mean percentages were 26% and 24% respectively. None of the above changes were statistically significant when the means were compared. Total sleep time (550±86 and 518±66 minutes respectively), sleep difficulty, REM latency periods and the number of REM cycles were not different before and after GH. While these data tend to suggest that there is a shift in the stage of sleep in these patients from slow wave III/IV to stage II sleep, they were not statistically significant. No other parameters are significantly effected. These data do not support the data found in animals who were shown to have increases in slow wave sleep after GH administration." @default.
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- W2117948488 date "1981-04-01" @default.
- W2117948488 modified "2023-10-18" @default.
- W2117948488 title "456 EFFECT OF GROWTH HORMONE THERAPY ON SLEEP" @default.
- W2117948488 doi "https://doi.org/10.1203/00006450-198104001-00468" @default.
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