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- W2117982300 endingPage "986" @default.
- W2117982300 startingPage "980" @default.
- W2117982300 abstract "Gastrointestinal distress, such as diarrhoea, cramping, vomiting, nausea and gastric pain are common among athletes during training and competition. The mechanisms that cause these symptoms are not fully understood. The stress of heat and oxidative damage during exercise causes disruption to intestinal epithelial cell tight junction proteins resulting in increased permeability to luminal endotoxins. The endotoxin moves into the blood stream leading to a systemic immune response. Tight junction integrity is altered by the phosphoylation state of the proteins occludin and claudins, and may be regulated by the type of exercise performed. Prolonged exercise and high-intensity exercise lead to an increase in key phosphorylation enzymes that ultimately cause tight junction dysfunction, but the mechanisms are different. The purpose of this review is to (1) explain the function and physiology of tight junction regulation, (2) discuss the effects of prolonged and high-intensity exercise on tight junction permeability leading to gastrointestinal distress and (3) review agents that may increase or decrease tight junction integrity during exercise." @default.
- W2117982300 created "2016-06-24" @default.
- W2117982300 creator A5030129505 @default.
- W2117982300 creator A5036536942 @default.
- W2117982300 creator A5043934141 @default.
- W2117982300 creator A5046088659 @default.
- W2117982300 creator A5053705167 @default.
- W2117982300 creator A5075958355 @default.
- W2117982300 date "2012-11-07" @default.
- W2117982300 modified "2023-10-16" @default.
- W2117982300 title "Exercise regulation of intestinal tight junction proteins" @default.
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