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- W2117989752 abstract "The present study aimed to examine the radioprotective effect of a nutraceutical supplement of yeast glucan with Zn bisglycinate against histological and biochemical changes induced by γ-irradiation. Animals received orally in water suspension (65 mg Glucan + 100 mg Zn bisglycinate kg -1 body weight for 5 consecutive days before irradiation & 7 days during the period of radiation exposure) (2 Gy x 4 delivered every other day). Results revealed that the major part of yeast extract was 1,3-β-D-glucan and confirm the existence of chelation in Zn bisglycinate. Histological examinations of different tissues (liver, heart, kidney and testis) showed that administration of the nutraceutical supplement has attenuated radiationinduced damaged and improved tissue architecture. The histological amelioration in the different tissues was accompanied by a remarkable decrease of their lipid peroxide levels. Moreover, the metabolic disorders accompanying tissue damage were significantly ameliorated. Changes in serum aspartate amino transferase (AST), alanine amino transferase (ALT), gamma glutamyl transferase γ-GT), acid phosphatase (ACP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities, urea, creatinine glucose content and lipid profile were significantly ameliorated, compared to corresponding values in irradiated rats. According to the obtained results 1,3-β-D-glucan with zinc bisglycinate might be considered a potent nutraceutical supplement with a remarkable radioprotective capacity." @default.
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- W2117989752 date "2008-01-01" @default.
- W2117989752 modified "2023-09-26" @default.
- W2117989752 title "Ameliorating Effects of Yeast Glucan with Zinc Bisglycinate on Histological and Biochemical Changes in γ-Irradiated Rats" @default.
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