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• W2118001641 abstract "The Trp53 tumor suppressor gene product (p53) functions in the nucleus to regulate proapoptotic genes, whereas cytoplasmic p53 directly activates proapoptotic Bcl-2 proteins to permeabilize mitochondria and initiate apoptosis. Here, we demonstrate that a tripartite nexus between Bcl-xL, cytoplasmic p53, and PUMA coordinates these distinct p53 functions. After genotoxic stress, Bcl-xL sequestered cytoplasmic p53. Nuclear p53 caused expression of PUMA , which then displaced p53 from Bcl-xL, allowing p53 to induce mitochondrial permeabilization. Mutant Bcl-xL that bound p53, but not PUMA, rendered cells resistant to p53-induced apoptosis irrespective of PUMA expression. Thus, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53." @default.
• W2118001641 created "2016-06-24" @default.
• W2118001641 creator A5016580341 @default.
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• W2118001641 date "2005-09-09" @default.
• W2118001641 modified "2023-10-18" @default.
• W2118001641 title "PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53" @default.
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• W2118001641 doi "https://doi.org/10.1126/science.1114297" @default.
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