Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118006087> ?p ?o ?g. }
- W2118006087 abstract "Cavin-3 is a tumor suppressor protein of unknown function. Using both in vivo and in vitro approaches, we show that cavin-3 dictates the balance between ERK and Akt signaling. Loss of cavin-3 increases Akt signaling at the expense of ERK, while gain of cavin-3 increases ERK signaling at the expense Akt. Cavin-3 facilitates signal transduction to ERK by anchoring caveolae to the membrane skeleton of the plasma membrane via myosin-1c. Caveolae are lipid raft specializations that contain an ERK activation module and loss of the cavin-3 linkage reduces the abundance of caveolae, thereby separating this ERK activation module from signaling receptors. Loss of cavin-3 promotes Akt signaling through suppression of EGR1 and PTEN. The in vitro consequences of the loss of cavin-3 include induction of Warburg metabolism (aerobic glycolysis), accelerated cell proliferation, and resistance to apoptosis. The in vivo consequences of cavin-3 knockout are increased lactate production and cachexia." @default.
- W2118006087 created "2016-06-24" @default.
- W2118006087 creator A5012970533 @default.
- W2118006087 creator A5023001996 @default.
- W2118006087 creator A5047635771 @default.
- W2118006087 creator A5055707568 @default.
- W2118006087 creator A5057059496 @default.
- W2118006087 creator A5064233753 @default.
- W2118006087 creator A5070413526 @default.
- W2118006087 creator A5073792441 @default.
- W2118006087 creator A5075824492 @default.
- W2118006087 date "2013-09-24" @default.
- W2118006087 modified "2023-10-15" @default.
- W2118006087 title "Cavin-3 dictates the balance between ERK and Akt signaling" @default.
- W2118006087 cites W1494401713 @default.
- W2118006087 cites W1521411817 @default.
- W2118006087 cites W1643087207 @default.
- W2118006087 cites W1748092353 @default.
- W2118006087 cites W1965039067 @default.
- W2118006087 cites W1972218893 @default.
- W2118006087 cites W1974284037 @default.
- W2118006087 cites W1976081253 @default.
- W2118006087 cites W1979254220 @default.
- W2118006087 cites W1980143302 @default.
- W2118006087 cites W1980773456 @default.
- W2118006087 cites W1982219839 @default.
- W2118006087 cites W1983235165 @default.
- W2118006087 cites W1984621921 @default.
- W2118006087 cites W1985850927 @default.
- W2118006087 cites W1986214532 @default.
- W2118006087 cites W1986812906 @default.
- W2118006087 cites W1986847123 @default.
- W2118006087 cites W1988269886 @default.
- W2118006087 cites W1990340849 @default.
- W2118006087 cites W1995032745 @default.
- W2118006087 cites W1996842617 @default.
- W2118006087 cites W1998450603 @default.
- W2118006087 cites W1999873712 @default.
- W2118006087 cites W2002594335 @default.
- W2118006087 cites W2003414227 @default.
- W2118006087 cites W2004385261 @default.
- W2118006087 cites W2005376689 @default.
- W2118006087 cites W2006033801 @default.
- W2118006087 cites W2008786310 @default.
- W2118006087 cites W2008869575 @default.
- W2118006087 cites W2009231148 @default.
- W2118006087 cites W2009886463 @default.
- W2118006087 cites W2009933321 @default.
- W2118006087 cites W2013317654 @default.
- W2118006087 cites W2013777294 @default.
- W2118006087 cites W2014058353 @default.
- W2118006087 cites W2021348596 @default.
- W2118006087 cites W2023179617 @default.
- W2118006087 cites W2026516266 @default.
- W2118006087 cites W2028986007 @default.
- W2118006087 cites W2029362226 @default.
- W2118006087 cites W2029634948 @default.
- W2118006087 cites W2032190558 @default.
- W2118006087 cites W2036284944 @default.
- W2118006087 cites W2037668423 @default.
- W2118006087 cites W2043659229 @default.
- W2118006087 cites W2043768800 @default.
- W2118006087 cites W2046699837 @default.
- W2118006087 cites W2049791243 @default.
- W2118006087 cites W2053100392 @default.
- W2118006087 cites W2053983181 @default.
- W2118006087 cites W2057724921 @default.
- W2118006087 cites W2060416249 @default.
- W2118006087 cites W2065010237 @default.
- W2118006087 cites W2065550928 @default.
- W2118006087 cites W2071577234 @default.
- W2118006087 cites W2074275713 @default.
- W2118006087 cites W2078304124 @default.
- W2118006087 cites W2079975816 @default.
- W2118006087 cites W2081259278 @default.
- W2118006087 cites W2084659421 @default.
- W2118006087 cites W2091436921 @default.
- W2118006087 cites W2095987251 @default.
- W2118006087 cites W2096797584 @default.
- W2118006087 cites W2100963977 @default.
- W2118006087 cites W2105754268 @default.
- W2118006087 cites W2110169410 @default.
- W2118006087 cites W2111833940 @default.
- W2118006087 cites W2113876813 @default.
- W2118006087 cites W2115809662 @default.
- W2118006087 cites W2122565002 @default.
- W2118006087 cites W2122906783 @default.
- W2118006087 cites W2122925019 @default.
- W2118006087 cites W2124317881 @default.
- W2118006087 cites W2124898208 @default.
- W2118006087 cites W2128847669 @default.
- W2118006087 cites W2129031030 @default.
- W2118006087 cites W2131131437 @default.
- W2118006087 cites W2132000251 @default.
- W2118006087 cites W2132693703 @default.
- W2118006087 cites W2133870709 @default.
- W2118006087 cites W2137565687 @default.
- W2118006087 cites W2137870551 @default.
- W2118006087 cites W2139959812 @default.
- W2118006087 cites W2140121036 @default.