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• W2118014773 abstract "A. fumigatus biofilms represent a problematic clinical entity, especially because of their recalcitrance to antifungal drugs, which poses a number of therapeutic implications for invasive aspergillosis, the most difficult-to-treat Aspergillus-related disease. While the antibiofilm activities of amphotericin B (AMB) deoxycholate and its lipid formulations (e.g., liposomal AMB [LAMB]) are well documented, the effectiveness of these drugs in combination with nonantifungal agents is poorly understood. In the present study, in vitro interactions between polyene antifungals Amphotericin (AMB) and liposomal Amphotericin (LAMB) with alginate lyase (AlgL), an enzyme degrading the polysaccharides produced as extracellular polymeric substances (EPSs) within the biofilm matrix, against A. fumigatus biofilms were evaluated by using atomic force microscopy (AFM). AFM was used to image and quantify the effects of AlgL-antifungal combinations on biofilm-growing hyphal cells. AFM analysis showed that when A. fumigatus biofilms were treated with AlgL or polyene alone, as well as with their combination, both a reduction of hyphal thicknesses and an increase of adhesive forces were observed compared to the findings for untreated controls, probably owing to the different action by the enzyme or the antifungal compounds. Interestingly, marked physical changes were noticed in A. fumigatus biofilms exposed to the AlgL-antifungal combinations compared with the physical characteristics detected after exposure to the antifungal alone, indicating that AlgL may enhance the antibiofilm activity of both AMB and LAMB, perhaps by disrupting the hypha-embedding EPSs and thus facilitating the drugs to reach biofilm cells. Our results suggest that a combination of AlgL and a polyene antifungal may prove to be a new therapeutic strategy for invasive aspergillosis." @default.
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• W2118014773 date "2014-09-30" @default.
• W2118014773 modified "2023-10-03" @default.
• W2118014773 title "Adhesive properties of Aspergillus fumigatus biofilms probed by atomic force microscopy and effects of alginate lyase enzyme" @default.
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• W2118014773 doi "https://doi.org/10.4081/microscopie.2014.4993" @default.
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