FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118032905> ?p ?o ?g. }

• W2118032905 abstract "The ability of mammalian cell lines to sustain cell specific productivity (Qp) over the full duration of bioprocess culture is a highly desirable phenotype, but the molecular basis for sustainable productivity has not been previously investigated in detail. In order to identify proteins that may be associated with a sustained productivity phenotype, we have conducted a proteomic profiling analysis of two matched pairs of monoclonal antibody-producing Chinese hamster ovary (CHO) cell lines that differ in their ability to sustain productivity over a 10 day fed-batch culture.Proteomic profiling of inherent differences between the two sets of comparators using 2D-DIGE (Difference Gel Electrophoresis) and LC-MS/MS resulted in the identification of 89 distinct differentially expressed proteins. Overlap comparisons between the two sets of cell line pairs identified 12 proteins (AKRIB8, ANXA1, ANXA4, EIF3I, G6PD, HSPA8, HSP90B1, HSPD1, NUDC, PGAM1, RUVBL1 and CNN3) that were differentially expressed in the same direction.These proteins may have an important role in sustaining high productivity of recombinant protein over the duration of a fed-batch bioprocess culture. It is possible that many of these proteins could be useful for future approaches to successfully manipulate or engineer CHO cells in order to sustain productivity of recombinant protein." @default.
• W2118032905 created "2016-06-24" @default.
• W2118032905 creator A5018053019 @default.
• W2118032905 creator A5027215596 @default.
• W2118032905 creator A5039366298 @default.
• W2118032905 creator A5063669238 @default.
• W2118032905 creator A5070489124 @default.
• W2118032905 creator A5077091444 @default.
• W2118032905 creator A5077752545 @default.
• W2118032905 creator A5081858870 @default.
• W2118032905 creator A5084141317 @default.
• W2118032905 creator A5086969209 @default.
• W2118032905 creator A5089401898 @default.
• W2118032905 date "2011-07-24" @default.
• W2118032905 modified "2023-10-18" @default.
• W2118032905 title "Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype" @default.
• W2118032905 cites W1968847190 @default.
• W2118032905 cites W1969264016 @default.
• W2118032905 cites W1972148441 @default.
• W2118032905 cites W1974505324 @default.
• W2118032905 cites W1984817670 @default.
• W2118032905 cites W1988010095 @default.
• W2118032905 cites W1997883534 @default.
• W2118032905 cites W1998051089 @default.
• W2118032905 cites W2001919111 @default.
• W2118032905 cites W2002029926 @default.
• W2118032905 cites W2010668098 @default.
• W2118032905 cites W2011958996 @default.
• W2118032905 cites W2022353826 @default.
• W2118032905 cites W2022775041 @default.
• W2118032905 cites W2025215273 @default.
• W2118032905 cites W2027852704 @default.
• W2118032905 cites W2034207323 @default.
• W2118032905 cites W2039827626 @default.
• W2118032905 cites W2042544794 @default.
• W2118032905 cites W2043433277 @default.
• W2118032905 cites W2056313779 @default.
• W2118032905 cites W2062697450 @default.
• W2118032905 cites W2070729846 @default.
• W2118032905 cites W2075241233 @default.
• W2118032905 cites W2075261924 @default.
• W2118032905 cites W2075808870 @default.
• W2118032905 cites W2083749028 @default.
• W2118032905 cites W2088910762 @default.
• W2118032905 cites W2097918041 @default.
• W2118032905 cites W2102024470 @default.
• W2118032905 cites W2123174753 @default.
• W2118032905 cites W2123793943 @default.
• W2118032905 cites W2124943966 @default.
• W2118032905 cites W2134217080 @default.
• W2118032905 cites W2142963315 @default.
• W2118032905 cites W2143604769 @default.
• W2118032905 cites W2170275957 @default.
• W2118032905 cites W2179172823 @default.
• W2118032905 cites W4231639351 @default.
• W2118032905 cites W4239595624 @default.
• W2118032905 doi "https://doi.org/10.1186/1472-6750-11-78" @default.
• W2118032905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3170212" @default.
• W2118032905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21781345" @default.
• W2118032905 hasPublicationYear "2011" @default.
• W2118032905 type Work @default.
• W2118032905 sameAs 2118032905 @default.
• W2118032905 citedByCount "59" @default.
• W2118032905 countsByYear W21180329052012 @default.
• W2118032905 countsByYear W21180329052013 @default.
• W2118032905 countsByYear W21180329052014 @default.
• W2118032905 countsByYear W21180329052015 @default.
• W2118032905 countsByYear W21180329052016 @default.
• W2118032905 countsByYear W21180329052017 @default.
• W2118032905 countsByYear W21180329052018 @default.
• W2118032905 countsByYear W21180329052019 @default.
• W2118032905 countsByYear W21180329052020 @default.
• W2118032905 countsByYear W21180329052021 @default.
• W2118032905 countsByYear W21180329052022 @default.
• W2118032905 crossrefType "journal-article" @default.
• W2118032905 hasAuthorship W2118032905A5018053019 @default.
• W2118032905 hasAuthorship W2118032905A5027215596 @default.
• W2118032905 hasAuthorship W2118032905A5039366298 @default.
• W2118032905 hasAuthorship W2118032905A5063669238 @default.
• W2118032905 hasAuthorship W2118032905A5070489124 @default.
• W2118032905 hasAuthorship W2118032905A5077091444 @default.
• W2118032905 hasAuthorship W2118032905A5077752545 @default.
• W2118032905 hasAuthorship W2118032905A5081858870 @default.
• W2118032905 hasAuthorship W2118032905A5084141317 @default.
• W2118032905 hasAuthorship W2118032905A5086969209 @default.
• W2118032905 hasAuthorship W2118032905A5089401898 @default.
• W2118032905 hasBestOaLocation W21180329051 @default.
• W2118032905 hasConcept C104317684 @default.
• W2118032905 hasConcept C104397665 @default.
• W2118032905 hasConcept C127716648 @default.
• W2118032905 hasConcept C151730666 @default.
• W2118032905 hasConcept C153911025 @default.
• W2118032905 hasConcept C175656101 @default.
• W2118032905 hasConcept C40767141 @default.
• W2118032905 hasConcept C46111723 @default.
• W2118032905 hasConcept C4916135 @default.
• W2118032905 hasConcept C54355233 @default.
• W2118032905 hasConcept C70721500 @default.
• W2118032905 hasConcept C81885089 @default.
• W2118032905 hasConcept C86803240 @default.

• next