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- W2118038516 abstract "Introduction: Erythropoietic protoporphyria (EPP) is characterized by incapacitating pain in the sunlight-exposed skin areas due to accumulation of the metabolite protoporphyrin. Until now, no effective prevention of phototoxicity has been available. Afamelanotide, an α-melanocyte-stimulating hormone (α-MSH) analogue and first-in-class drug, induces melanin formation. The skin tan diminishes activation of protoporphyrin by reducing the sunlight penetration into the dermis. For continuous photoprotection, afamelanotide is applied every second month as a 16-mg controlled release implant. Areas covered: In two Phase II and two Phase III trials in Europe, Australia and the US afamelanotide significantly reduced EPP-related phototoxic pain when tested in > 250 patients. To date, safety including compassionate use programs for up to 6 years appears to be excellent, including only nausea and flushing for a brief time after administration. No immunogenicity was observed. Approval for EPP treatment is pending at t..." @default.
- W2118038516 created "2016-06-24" @default.
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- W2118038516 date "2013-03-11" @default.
- W2118038516 modified "2023-09-23" @default.
- W2118038516 title "Afamelanotide for the treatment of erythropoietic protoporphyria" @default.
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- W2118038516 doi "https://doi.org/10.1517/21678707.2013.780969" @default.
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