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• W2118045668 abstract "(See the Major Article by Ogrinc et al on pages 501–9.)Lyme borreliosis occurs in parts of both North America and Eurasia. The most common clinical manifestation is the characteristic skin lesion erythema migrans (EM) [1]. Other manifestations include arthritis, meningitis, mononeuritis multiplex, and myocarditis. In North America, the only well-established cause of Lyme borreliosis is Borrelia burgdorferi, whereas in Europe most cases are caused by Borrelia afzelii or Borrelia garinii and only a minority by B. burgdorferi [1].Different species of Lyme borrelia have propensities to cause different clinical manifestations [1, 2]. Evidence based on culture, polymerase chain reaction (PCR) testing, serologic patterns, or other methodologies indicates that B. garinii is the species of Lyme Borrelia most often associated with European Lyme neuroborreliosis [2–4]. Although B. burgdorferi is well known to cause Lyme neuroborreliosis in the United States, available evidence indicates that infection with particular subtypes is disproportionately associated with neurologic involvement [5, 6]. Thus, neurotropism is a virulence characteristic not equally shared by all Lyme Borrelia species or by all subtypes of a given species. The same is true for species and strains of relapsing fever Borrelia [7, 8].In this issue of Clinical Infectious Disease, Ogrinc et al [9] report the results of lumbar punctures performed on a subgroup of patients with EM with symptoms or signs that raised the possibility of Lyme meningitis. A primary finding was that patients with radicular pain, peripheral facial nerve palsy, and/or meningeal signs were likely to have meningeal inflammation. Symptoms of headache, memory or concentration problems, paresthesias, dizziness, fatigue, neck pain, and nausea or vomiting were not indicative of meningitis. This critically important observation, which mirrors our own experience in the United States, reinforces one of the core tenets of clinical neurology. Neurologic disease—meaning disorders that damage the nervous system—causes objective changes in nervous system function. Nonspecific symptoms, such as headache, fatigue, difficulty concentrating, or those listed above, may reflect altered functioning of the nervous system but do not per se indicate nervous system damage. Such altered functioning is typically caused by physiologic changes such as occur in systemic illness. Although it is commonplace in some circles to suggest that these nonspecific symptoms constitute evidence of Lyme neuroborreliosis, this assertion has not been supported by prior scientific studies and is refuted by Ogrinc et al's report [9].The investigators attempted to culture Borrelia from skin, blood, and cerebrospinal fluid (CSF). Their observation that recent prior antibiotic therapy eliminates or markedly reduces culture positivity is very much in accord with our own [10]. In our experience, even just 1 or 2 doses of antibiotic will negatively affect the yield of borrelial cultures.In the Ogrinc et al study [9], only 5 of the 31 (16.1%) patients with meningitis had a positive CSF culture, but 4 of the 5 (80%) positive cultures grew B. garinii. Indirect evidence, however, suggested that B. garinii was responsible for many of the other cases. Of the 12 patients with a positive skin culture for B. garinii, 9 (75%) had CSF pleocytosis, compared with only 3 of 41 (7.3%) patients with a positive skin culture for B. afzelii (P < .001). In addition, among the 12 patients with both a positive skin culture and CSF pleocytosis, 9 (75%) were infected with B. garinii.Another remarkable observation was that CSF pleocytosis was more common in patients whose EM skin lesions grew at a substantially faster rate. The largest EM diameter increased at a rate of 2 cm per day in patients with CSF pleocytosis compared with just over 1 cm per day in those without CSF pleocytosis [9]. In a prior study of culture-confirmed Slovenian patients with EM, of whom 53 had B. garinii and 200 B. afzelii infection, the rate of increase of the largest EM diameter in B. garinii–infected patients was also approximately twice that of B. afzelii–infected patients [11]. In the latter study, the daily increase in the EM surface area was 12.5 cm2 in B. garinii–infected patients compared with just 3 cm2 per day in those with B. afzelii infection (P < .001). These findings also suggest that most of the cases of Lyme meningitis in the Ogrinc et al study [9] were caused by B. garinii.What accounts for the neurotropism of B. garinii or for its ability to cause more rapid expansion of EM skin lesions has not been defined [12–14]. It has been suggested that B. garinii may cause radiculoneuritis by neural spread [15, 16] rather than by hematogenous dissemination, which would be consistent with the infrequency of positive blood cultures for B. garinii in patients with proven B. garinii skin or CSF infection in the Ogrinc et al study [9]. However, it also could be argued that an insufficient quantity of plasma was cultured to exclude spirochetemia. Studies in the United States have suggested that yields are much greater if at least 9 mL of plasma is cultured [17], whereas 4 mL to 5 mL was cultured by Ogrinc et al [9]. However, multiple EM skin lesions, which are thought to arise by hematogenous dissemination from the original site of the tick inoculation of the spirochete to other skin sites, were not found disproportionately in patients with meningitis. This argues against the hypothesis that spirochetemia went undetected. In a prior Slovenian study [3], evidence for radiculoneuritis was present in 65% of 23 patients whose CSF cultures grew B. garinii, suggesting that dorsal root, dorsal root ganglia, or other peripheral nerve locations may be common sites of infection in neuroborreliosis due to B. garinii infection. Based on the consistently low yields of culture and the generally low rates of positive PCR assays on CSF samples of Lyme neuroborreliosis cases in both Europe and the United States [3, 9, 18, 19], it seems clear that spirochetes are present in low numbers or not at all in the subarachnoid space of such patients.In the Ogrinc et al study [9], B. afzelii grew from the CSF of 1 of the 130 (0.76%) patients without CSF pleocytosis and represented the sole positive CSF isolate from these patients. To interpret this observation properly, it would have been desirable to have confirmed this finding by an independent method such as a PCR assay. Without confirmation, it is impossible to exclude laboratory contamination as the cause of this phenomenon, which has been described for CSF cultures by other investigators [20]. However, other possible explanations include very early infection preceding the development of pleocytosis, contamination of CSF with blood-borne spirochetes introduced by the lumbar puncture needle, or central nervous system invasion without pathology, as has been postulated to occur with Treponema pallidum in certain patients with early syphilis [21].The presence of EM reliably establishes the diagnosis of Lyme disease. Thus, patients with EM who in addition have seventh nerve palsy, meningeal signs, or radiculopathy can quite reasonably be considered as having Lyme neuroborreliosis, provided that coinfection with a tick-borne encephalitis virus is excluded. Thus, the findings in the Ogrinc et al study [9] are helpful in clarifying the pathogenesis of various symptom complexes in Lyme borreliosis. However, the implications for therapy are less clear. Because studies in Europe have demonstrated that treatment of Lyme neuroborreliosis with oral doxycycline is as effective as parenteral therapy with ceftriaxone [22, 23], documentation of CSF abnormalities would not necessarily alter the choice of treatment. Although CSF analysis might provide a baseline for judging treatment response, currently recommended antimicrobial regimens appear to be sufficiently effective that serial CSF examinations are generally unnecessary. Thus, outside of a research study, lumbar puncture is probably not necessary in the majority of European patients with EM, whether or not there is a suspicion of neurologic involvement." @default.
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• W2118045668 title "Editorial Commentary: Toward a Better Understanding of European Lyme Neuroborreliosis" @default.
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