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- W2118045677 abstract "Recent advents in magnetic resonance spectroscopy (MRS) techniques permit subsequent microarray analysis over the entire human transcriptome in the same tissue biopsies. However, extracting information from such immense quantities of data is limited by difficulties in recognizing and evaluating the relevant patterns of apparent gene expression in the context of the existing knowledge of phenotypes by histopathology. Using a quantitative approach derived from a knowledge base of pathology findings, we present a novel methodology used to process genome-wide transcription and MRS data. This methodology was tested to examine metabolite and genome-wide profiles in MRS and RNA in 55 biopsies from human subjects with brain tumors with ~100% certainty. With the guidance of histopathology and clinical outcome, 15 genes with the assistance of 15 MRS metabolites were able to be distinguished by tumor categories and the prediction of survival was better than when either method was used alone. This new method, combining MRS, genomics, statistics and biological content, improves the typing and understanding of the complexity of human brain tumors, and assists in the search for novel tumor biomarkers. It is an important step for novel drug development, it generates testable hypotheses regarding neoplasia and promises to guide human brain tumor therapy provided improved in vivo methods for monitoring response to therapy are developed." @default.
- W2118045677 created "2016-06-24" @default.
- W2118045677 creator A5007939716 @default.
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- W2118045677 date "2011-04-01" @default.
- W2118045677 modified "2023-10-01" @default.
- W2118045677 title "Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone" @default.
- W2118045677 cites W1484914631 @default.
- W2118045677 cites W1491866861 @default.
- W2118045677 cites W1508295900 @default.
- W2118045677 cites W1518290724 @default.
- W2118045677 cites W1529712966 @default.
- W2118045677 cites W1551136530 @default.
- W2118045677 cites W1571958837 @default.
- W2118045677 cites W1575776229 @default.
- W2118045677 cites W1771155305 @default.
- W2118045677 cites W1797946869 @default.
- W2118045677 cites W1824684008 @default.
- W2118045677 cites W1859114794 @default.
- W2118045677 cites W1922687742 @default.
- W2118045677 cites W1945743004 @default.
- W2118045677 cites W1963599558 @default.
- W2118045677 cites W1965723744 @default.
- W2118045677 cites W1965772205 @default.
- W2118045677 cites W1967111227 @default.
- W2118045677 cites W1969731334 @default.
- W2118045677 cites W1970185365 @default.
- W2118045677 cites W1970472404 @default.
- W2118045677 cites W1971278063 @default.
- W2118045677 cites W1973179309 @default.
- W2118045677 cites W1976214427 @default.
- W2118045677 cites W1976806248 @default.
- W2118045677 cites W1977822330 @default.
- W2118045677 cites W1978868443 @default.
- W2118045677 cites W1980560915 @default.
- W2118045677 cites W1984786335 @default.
- W2118045677 cites W1985221365 @default.
- W2118045677 cites W1989130394 @default.
- W2118045677 cites W1994416681 @default.
- W2118045677 cites W1995580330 @default.
- W2118045677 cites W1998061827 @default.
- W2118045677 cites W1998345137 @default.
- W2118045677 cites W2004554921 @default.
- W2118045677 cites W2004580999 @default.
- W2118045677 cites W2009272688 @default.
- W2118045677 cites W2010538596 @default.
- W2118045677 cites W2016242322 @default.
- W2118045677 cites W2019313836 @default.
- W2118045677 cites W2019525644 @default.
- W2118045677 cites W2020291298 @default.
- W2118045677 cites W2024178757 @default.
- W2118045677 cites W2030048504 @default.
- W2118045677 cites W2030074887 @default.
- W2118045677 cites W2034154329 @default.
- W2118045677 cites W2038393971 @default.
- W2118045677 cites W2040394747 @default.
- W2118045677 cites W2043014380 @default.
- W2118045677 cites W2043507486 @default.
- W2118045677 cites W2044342547 @default.
- W2118045677 cites W2047848539 @default.
- W2118045677 cites W2048169243 @default.
- W2118045677 cites W2048377708 @default.
- W2118045677 cites W2052258308 @default.
- W2118045677 cites W2054178856 @default.
- W2118045677 cites W2055076603 @default.
- W2118045677 cites W2056437403 @default.
- W2118045677 cites W2058280783 @default.
- W2118045677 cites W2063382290 @default.
- W2118045677 cites W2063630719 @default.
- W2118045677 cites W2065859014 @default.
- W2118045677 cites W2071613912 @default.
- W2118045677 cites W2072506631 @default.
- W2118045677 cites W2072868135 @default.
- W2118045677 cites W2076147631 @default.
- W2118045677 cites W2078809426 @default.
- W2118045677 cites W2080483074 @default.
- W2118045677 cites W2081379098 @default.
- W2118045677 cites W2081944866 @default.
- W2118045677 cites W2084400475 @default.
- W2118045677 cites W2088677979 @default.
- W2118045677 cites W2088851040 @default.
- W2118045677 cites W2089670830 @default.
- W2118045677 cites W2089798367 @default.
- W2118045677 cites W2092823267 @default.
- W2118045677 cites W2093575539 @default.
- W2118045677 cites W2093764184 @default.
- W2118045677 cites W2093816990 @default.
- W2118045677 cites W2097665972 @default.
- W2118045677 cites W2099032401 @default.
- W2118045677 cites W2099841076 @default.
- W2118045677 cites W2102794349 @default.
- W2118045677 cites W2104235597 @default.