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- W2118049762 abstract "The constituents of seminal fluid are a complex mixture of proteins and other molecules, most of whose functions have yet to be determined and many of which are rapidly evolving. As a step in elucidating the roles of these proteins and exposing potential functional similarities hidden by their rapid evolution, we performed comparative structural modeling on 28 of 52 predicted seminal proteins produced in the Drosophila melanogaster male accessory gland. Each model was characterized by defining residues likely to be important for structure and function. Comparisons of known protein structures with predicted accessory gland proteins (Acps) revealed similarities undetectable by primary sequence alignments. The structures predict that Acps fall into several categories: regulators of proteolysis, lipid modifiers, immunity/protection, sperm-binding proteins, and peptide hormones. The comparative structural modeling approach indicates that major functional classes of mammalian and Drosophila seminal fluid proteins are conserved, despite differences in reproductive strategies. This is particularly striking in the face of the rapid protein sequence evolution that characterizes many reproductive proteins, including Drosophila and mammalian seminal proteins." @default.
- W2118049762 created "2016-06-24" @default.
- W2118049762 creator A5034156995 @default.
- W2118049762 creator A5058671397 @default.
- W2118049762 creator A5073566367 @default.
- W2118049762 creator A5089592476 @default.
- W2118049762 date "2004-09-02" @default.
- W2118049762 modified "2023-10-14" @default.
- W2118049762 title "Comparative structural modeling and inference of conserved protein classes in <i>Drosophila</i> seminal fluid" @default.
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- W2118049762 doi "https://doi.org/10.1073/pnas.0405579101" @default.
- W2118049762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/518759" @default.
- W2118049762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15345744" @default.
- W2118049762 hasPublicationYear "2004" @default.
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