FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118052242> ?p ?o ?g. }

• W2118052242 endingPage "20207" @default.
• W2118052242 startingPage "20197" @default.
• W2118052242 abstract "The obligate intracellular apicomplexan parasites, e.g. Toxoplasma gondii and Plasmodium species, induce an IFNγ-driven induction of host indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme of tryptophan catabolism in the kynurenine pathway. Induction of IDO1 supposedly depletes cellular levels of tryptophan in host cells, which is proposed to inhibit the in vitro growth of auxotrophic pathogens. In vivo function of IDO during infections, however, is not clear, let alone controversial. We show that Eimeria falciformis, an apicomplexan parasite infecting the mouse caecum, induces IDO1 in the epithelial cells of the organ, and the enzyme expression coincides with the parasite development. The absence or inhibition of IDO1/2 and of two downstream enzymes in infected animals is detrimental to the Eimeria growth. The reduced parasite yield is not due to a lack of an immunosuppressive effect of IDO1 in the parasitized IDO1(-/-) or inhibitor-treated mice because they did not show an accentuated Th1 and IFNγ response. Noticeably, the parasite development is entirely rescued by xanthurenic acid, a by-product of tryptophan catabolism inducing exflagellation in male gametes of Plasmodium in the mosquito mid-gut. Our data demonstrate a conceptual subversion of the host defense (IFNγ, IDO) by an intracellular pathogen for progression of its natural life cycle. Besides, we show utility of E. falciformis, a monoxenous parasite of a well appreciated host, i.e. mouse, to identify in vivo factors underlying the parasite-host interactions." @default.
• W2118052242 created "2016-06-24" @default.
• W2118052242 creator A5000426837 @default.
• W2118052242 creator A5045813441 @default.
• W2118052242 creator A5066931373 @default.
• W2118052242 creator A5078849410 @default.
• W2118052242 date "2012-06-01" @default.
• W2118052242 modified "2023-10-16" @default.
• W2118052242 title "Apicomplexan Parasite, Eimeria falciformis, Co-opts Host Tryptophan Catabolism for Life Cycle Progression in Mouse" @default.
• W2118052242 cites W1494303284 @default.
• W2118052242 cites W1504661297 @default.
• W2118052242 cites W1507391401 @default.
• W2118052242 cites W1564721318 @default.
• W2118052242 cites W1585200928 @default.
• W2118052242 cites W1605075022 @default.
• W2118052242 cites W1607682771 @default.
• W2118052242 cites W1622259963 @default.
• W2118052242 cites W1648872901 @default.
• W2118052242 cites W1834981029 @default.
• W2118052242 cites W1892959235 @default.
• W2118052242 cites W1964709968 @default.
• W2118052242 cites W1974401900 @default.
• W2118052242 cites W1975929837 @default.
• W2118052242 cites W1983052331 @default.
• W2118052242 cites W1983113619 @default.
• W2118052242 cites W1992517022 @default.
• W2118052242 cites W1993679430 @default.
• W2118052242 cites W2003197988 @default.
• W2118052242 cites W2008878335 @default.
• W2118052242 cites W2012883395 @default.
• W2118052242 cites W2014527159 @default.
• W2118052242 cites W2015260577 @default.
• W2118052242 cites W2016823905 @default.
• W2118052242 cites W2017570284 @default.
• W2118052242 cites W2022430924 @default.
• W2118052242 cites W2037354525 @default.
• W2118052242 cites W2044747539 @default.
• W2118052242 cites W2053217888 @default.
• W2118052242 cites W2072078248 @default.
• W2118052242 cites W2120727992 @default.
• W2118052242 cites W2123654285 @default.
• W2118052242 cites W2137988168 @default.
• W2118052242 cites W2138558289 @default.
• W2118052242 cites W2139518224 @default.
• W2118052242 cites W2140657592 @default.
• W2118052242 cites W2146914242 @default.
• W2118052242 cites W2147547451 @default.
• W2118052242 cites W2151270618 @default.
• W2118052242 cites W2152857351 @default.
• W2118052242 cites W2154565921 @default.
• W2118052242 cites W2157144001 @default.
• W2118052242 cites W2163525487 @default.
• W2118052242 cites W2165116301 @default.
• W2118052242 cites W2165777029 @default.
• W2118052242 cites W2166788119 @default.
• W2118052242 cites W2167147409 @default.
• W2118052242 cites W2167897482 @default.
• W2118052242 cites W2282894338 @default.
• W2118052242 cites W4313331812 @default.
• W2118052242 doi "https://doi.org/10.1074/jbc.m112.351999" @default.
• W2118052242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3370202" @default.
• W2118052242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22535959" @default.
• W2118052242 hasPublicationYear "2012" @default.
• W2118052242 type Work @default.
• W2118052242 sameAs 2118052242 @default.
• W2118052242 citedByCount "22" @default.
• W2118052242 countsByYear W21180522422012 @default.
• W2118052242 countsByYear W21180522422013 @default.
• W2118052242 countsByYear W21180522422014 @default.
• W2118052242 countsByYear W21180522422015 @default.
• W2118052242 countsByYear W21180522422016 @default.
• W2118052242 countsByYear W21180522422017 @default.
• W2118052242 countsByYear W21180522422018 @default.
• W2118052242 countsByYear W21180522422019 @default.
• W2118052242 countsByYear W21180522422021 @default.
• W2118052242 countsByYear W21180522422022 @default.
• W2118052242 countsByYear W21180522422023 @default.
• W2118052242 crossrefType "journal-article" @default.
• W2118052242 hasAuthorship W2118052242A5000426837 @default.
• W2118052242 hasAuthorship W2118052242A5045813441 @default.
• W2118052242 hasAuthorship W2118052242A5066931373 @default.
• W2118052242 hasAuthorship W2118052242A5078849410 @default.
• W2118052242 hasBestOaLocation W21180522421 @default.
• W2118052242 hasConcept C126831891 @default.
• W2118052242 hasConcept C136764020 @default.
• W2118052242 hasConcept C153726182 @default.
• W2118052242 hasConcept C181199279 @default.
• W2118052242 hasConcept C203014093 @default.
• W2118052242 hasConcept C2776706248 @default.
• W2118052242 hasConcept C2777976947 @default.
• W2118052242 hasConcept C2778675580 @default.
• W2118052242 hasConcept C41008148 @default.
• W2118052242 hasConcept C515207424 @default.
• W2118052242 hasConcept C54355233 @default.
• W2118052242 hasConcept C55493867 @default.
• W2118052242 hasConcept C71928629 @default.
• W2118052242 hasConcept C79879829 @default.
• W2118052242 hasConcept C83478079 @default.

• next