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• W2118053675 abstract "The binding of aclacinomycin A to DNA was investigated spectrophotometrically under equilibrium conditions. The self-association behaviour of aclacinomycin A was identified as dimerization. Based on a model of overlapping potential binding sites the subsequent results were obtained: equilibrium constant of cooperative binding K=(7.58±2.15)×106 M-1, size of a binding site α=3.98± 0.14 base pairs, cooperativity parameter σ=0.12±0.10. These parameters were compared with those of adriamycin, daunomycin, and iremycin to draw some conclusions regarding the structural specialities of aclacinomycin A." @default.
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• W2118053675 date "1983-01-01" @default.
• W2118053675 modified "2023-09-26" @default.
• W2118053675 title "Interaction of anthracycline antibiotics with biopolymers. VIII. binding parameters of aclacinomycin A to DNA." @default.
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• W2118053675 doi "https://doi.org/10.7164/antibiotics.36.1222" @default.
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