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• W2118054399 abstract "Salivary gland cells are joined by junctional complexes consisting of a tight junction (TJ), zonula adherens and one or more desmosomes. TJs regulate paracellular permeability, maintain separate apical and basolateral membrane domains, and serve as signaling centers. We examined TJs of mouse submandibular glands (SMG) in thin sections and freeze-fracture replicas. TJs between acinar cells and between intercalated duct cells had 2–6 parallel strands on the protoplasmic fracture face, with occasional branches, interconnections and free ends, and corresponding grooves on the extracellular face. Granular duct cell TJs had 2–30 strands, a depth of ≤0.5 μm, and occasional loops extending further basally. Where 3 or 4 cells met, the TJs extended basally ≤1 μm and consisted of 2 parallel boundary strands into which the apical strands inserted. Quantitative analyses showed significant differences in TJ complexity, measured by fractal geometry, and strand number of acinar compared to granular duct cells, and a greater number of strands in male compared to female granular ducts. Pilocarpine stimulation increased TJ strand number in female acinar cells, and increased complexity of male granular duct cell TJs. As the salivary gland water channel aquaporin 5 (AQP5) has been proposed to functionally interact with TJs to regulate salivary fluid composition, we also studied glands from AQP5 knock-out mice. In males lacking AQP5, granular duct TJs were more complex than those of wild-type mice, and exhibited more strands following pilocarpine stimulation. The results demonstrate specific gender, cell type and genetic differences in TJ structure and response to stimulation. Anat Rec, 2010. © 2009 Wiley-Liss, Inc." @default.
• W2118054399 created "2016-06-24" @default.
• W2118054399 creator A5036632737 @default.
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• W2118054399 date "2009-11-06" @default.
• W2118054399 modified "2023-10-15" @default.
• W2118054399 title "The Structure of Tight Junctions in Mouse Submandibular Gland" @default.
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• W2118054399 doi "https://doi.org/10.1002/ar.21029" @default.
• W2118054399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19899114" @default.
• W2118054399 hasPublicationYear "2009" @default.
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