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- W2118076811 abstract "Despite their presence in many tissues and their potential implication in various disease states, low-voltage activated T-type calcium channels (T-channels) have only recently become targets of interest. Unfortunately, the lack of selective T-channel blockers has hampered further characterisation of these channels. The recent availability of cloned T-channels, the CaV3 proteins, facilitates identification of novel T-channel blockers. Also, studies performed in knockout animals have fostered novel interest. Selective inhibition of T-channels may have clinical importance in cardiovascular diseases, some forms of epilepsy, sleep disorders, pain and possibly cancer. This review focuses on novel research approaches to discover potent and selective T-channel modulators. These molecules may be potential drugs for treating human diseases, as well as important tools to decipher the physiological role of these channels." @default.
- W2118076811 created "2016-06-24" @default.
- W2118076811 creator A5041198374 @default.
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- W2118076811 date "2007-04-27" @default.
- W2118076811 modified "2023-10-17" @default.
- W2118076811 title "Towards the discovery of novel T-type calcium channel blockers" @default.
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- W2118076811 doi "https://doi.org/10.1517/14728222.11.5.717" @default.
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