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- W2118079454 abstract "The involvement of syntaxin, an ω-conotoxin-sensitive Ca2+ channel-associated protein, in acetylcholine release was studied at synapses formed between rat sympathetic neurons in culture. Transmission at these synapses involved ω-conotoxin-sensitive Ca2+ channels because a dose-dependent inhibition was observed when ω-conotoxin was bath-applied. Confocal microscope examination of immunofluorescent staining showed that syntaxin had a similar distribution to synaptic vesicle-associated membrane proteins, synaptophysin and vesicle-associated membrane protein/synaptobrevin-2, indicating that syntaxin molecules are concentrated in the presynaptic terminals. Botulinum neurotoxin C1 applied extracellularly or intracellularly into presynaptic neurons blocked synaptic transmission. Introduction of a monoclonal antibody, or polyclonal antibodies, to syntaxin into the presynaptic neuron depressed the evoked release of acetylcholine without affecting Ca2+ influx through Ca2+ channels. These results suggest that syntaxin plays an important role in release of neurotransmitter by a nerve impulse and that this mechanism is downstream of Ca2+ influx." @default.
- W2118079454 created "2016-06-24" @default.
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- W2118079454 date "1995-04-01" @default.
- W2118079454 modified "2023-10-12" @default.
- W2118079454 title "Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not Ca2+ channel activity" @default.
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- W2118079454 doi "https://doi.org/10.1016/0306-4522(94)00508-3" @default.
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