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• W2118087448 endingPage "4943" @default.
• W2118087448 startingPage "4943" @default.
• W2118087448 abstract "The term Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is a poor descriptor of the syndrome described by Lynch. Over the last decade, the term has been applied to heterogeneous groups of families meeting limited clinical criteria, for example the Amsterdam criteria. It is now apparent that not all Amsterdam criteria-positive families have the Lynch syndrome. The term HNPCC has also been applied to clinical scenarios in which CRCs with DNA microsatellite instability are diagnosed but in which there is no vertical transmission of an altered DNA mismatch repair (MMR) gene. A term that has multiple, mutually incompatible meanings is highly problematic, particularly when it may influence the management of an individual family. The Lynch syndrome is best understood as a hereditary predisposition to malignancy that is explained by a germline mutation in a DNA MMR gene. The diagnosis does not depend in an absolute sense on any particular family pedigree structure or age of onset of malignancy. Families with a strong family history of colorectal cancer that do not have Lynch syndrome have been grouped as 'Familial Colorectal Cancer Type-X'. The first step in characterizing these cancer families is to distinguish them from Lynch syndrome. The term HNPCC no longer serves any useful purpose and should be phased out." @default.
• W2118087448 created "2016-06-24" @default.
• W2118087448 creator A5010741320 @default.
• W2118087448 date "2006-01-01" @default.
• W2118087448 modified "2023-09-23" @default.
• W2118087448 title "Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term" @default.
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• W2118087448 cites W1569141172 @default.
• W2118087448 cites W164655235 @default.
• W2118087448 cites W172317727 @default.
• W2118087448 cites W1926715094 @default.
• W2118087448 cites W1934971502 @default.
• W2118087448 cites W1954660898 @default.
• W2118087448 cites W1969520081 @default.
• W2118087448 cites W1975048070 @default.
• W2118087448 cites W1977284533 @default.
• W2118087448 cites W1979372421 @default.
• W2118087448 cites W1980178943 @default.
• W2118087448 cites W1981112371 @default.
• W2118087448 cites W1986883444 @default.
• W2118087448 cites W1986937402 @default.
• W2118087448 cites W1990968130 @default.
• W2118087448 cites W1992212767 @default.
• W2118087448 cites W1994742596 @default.
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• W2118087448 cites W2000042026 @default.
• W2118087448 cites W2000879550 @default.
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• W2118087448 cites W2007420407 @default.
• W2118087448 cites W2007920489 @default.
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• W2118087448 cites W2039220388 @default.
• W2118087448 cites W2043278290 @default.
• W2118087448 cites W2044643325 @default.
• W2118087448 cites W2047420232 @default.
• W2118087448 cites W2050026996 @default.
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• W2118087448 doi "https://doi.org/10.3748/wjg.v12.i31.4943" @default.
• W2118087448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4087395" @default.
• W2118087448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16937488" @default.
• W2118087448 hasPublicationYear "2006" @default.
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