FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118096986> ?p ?o ?g. }

• W2118096986 abstract "Although most reports describe the protein kinase integrin-linked kinase (ILK) as a proto-oncogene, occasional studies detail opposing functions in the regulation of normal and transformed cell proliferation, differentiation, and apoptosis. Here, we demonstrated that ILK functions as an oncogene in the highly aggressive pediatric sarcoma alveolar rhabdomyosarcoma (ARMS) and as a tumor suppressor in the related embryonal rhabdomyosarcoma (ERMS). These opposing functions hinge on signaling through a noncanonical ILK target, JNK1, to the proto-oncogene c-Jun. RNAi-mediated depletion of ILK induced activation of JNK and its target, c-Jun, resulting in growth of ERMS cells, whereas in ARMS cells, it led to loss of JNK/c-Jun signaling and suppression of growth both in vitro and in vivo. Ectopic expression of the fusion gene characteristic of ARMS (paired box 3-forkhead homolog in rhabdomyosarcoma [PAX3-FKHR]) in ERMS cells was sufficient to convert them to an ARMS signaling phenotype and render ILK activity oncogenic. Furthermore, restoration of JNK1 in ARMS reestablished a tumor-suppressive function for ILK. These findings indicate what we believe to be a novel effector pathway regulated by ILK, provide a mechanism for interconversion of oncogenic and tumor-suppressor functions of a single regulatory protein based on the genetic background of the tumor cells, and suggest a rationale for tailored therapy of rhabdomyosarcoma based on the different activities of ILK." @default.
• W2118096986 created "2016-06-24" @default.
• W2118096986 creator A5027678095 @default.
• W2118096986 creator A5043603303 @default.
• W2118096986 creator A5047270721 @default.
• W2118096986 creator A5059546406 @default.
• W2118096986 creator A5082589131 @default.
• W2118096986 creator A5090452550 @default.
• W2118096986 date "2009-05-26" @default.
• W2118096986 modified "2023-09-30" @default.
• W2118096986 title "JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma" @default.
• W2118096986 cites W1572174728 @default.
• W2118096986 cites W1968137943 @default.
• W2118096986 cites W1971753613 @default.
• W2118096986 cites W1988242023 @default.
• W2118096986 cites W1988246938 @default.
• W2118096986 cites W1991083835 @default.
• W2118096986 cites W1992101010 @default.
• W2118096986 cites W1994219871 @default.
• W2118096986 cites W1996567361 @default.
• W2118096986 cites W2004806132 @default.
• W2118096986 cites W2008182675 @default.
• W2118096986 cites W2010385877 @default.
• W2118096986 cites W2015062933 @default.
• W2118096986 cites W2020850126 @default.
• W2118096986 cites W2024345327 @default.
• W2118096986 cites W2029650811 @default.
• W2118096986 cites W2038373302 @default.
• W2118096986 cites W2045027538 @default.
• W2118096986 cites W2047386879 @default.
• W2118096986 cites W2050108686 @default.
• W2118096986 cites W2051504882 @default.
• W2118096986 cites W2060136332 @default.
• W2118096986 cites W2063238994 @default.
• W2118096986 cites W2065769290 @default.
• W2118096986 cites W2069427120 @default.
• W2118096986 cites W2072903143 @default.
• W2118096986 cites W2075300416 @default.
• W2118096986 cites W2075811389 @default.
• W2118096986 cites W2094799740 @default.
• W2118096986 cites W2095661018 @default.
• W2118096986 cites W2098157104 @default.
• W2118096986 cites W2102352112 @default.
• W2118096986 cites W2114570899 @default.
• W2118096986 cites W2118719170 @default.
• W2118096986 cites W2127372364 @default.
• W2118096986 cites W2135020532 @default.
• W2118096986 cites W2144764610 @default.
• W2118096986 cites W2151041025 @default.
• W2118096986 cites W2151881633 @default.
• W2118096986 cites W2159492594 @default.
• W2118096986 cites W2160417212 @default.
• W2118096986 cites W2170588832 @default.
• W2118096986 cites W2172107548 @default.
• W2118096986 cites W4230009137 @default.
• W2118096986 doi "https://doi.org/10.1172/jci37958" @default.
• W2118096986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2689127" @default.
• W2118096986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19478459" @default.
• W2118096986 hasPublicationYear "2009" @default.
• W2118096986 type Work @default.
• W2118096986 sameAs 2118096986 @default.
• W2118096986 citedByCount "9" @default.
• W2118096986 countsByYear W21180969862012 @default.
• W2118096986 countsByYear W21180969862014 @default.
• W2118096986 countsByYear W21180969862015 @default.
• W2118096986 countsByYear W21180969862016 @default.
• W2118096986 countsByYear W21180969862017 @default.
• W2118096986 countsByYear W21180969862019 @default.
• W2118096986 crossrefType "journal-article" @default.
• W2118096986 hasAuthorship W2118096986A5027678095 @default.
• W2118096986 hasAuthorship W2118096986A5043603303 @default.
• W2118096986 hasAuthorship W2118096986A5047270721 @default.
• W2118096986 hasAuthorship W2118096986A5059546406 @default.
• W2118096986 hasAuthorship W2118096986A5082589131 @default.
• W2118096986 hasAuthorship W2118096986A5090452550 @default.
• W2118096986 hasBestOaLocation W21180969861 @default.
• W2118096986 hasConcept C121608353 @default.
• W2118096986 hasConcept C142724271 @default.
• W2118096986 hasConcept C184235292 @default.
• W2118096986 hasConcept C2776522094 @default.
• W2118096986 hasConcept C2777176876 @default.
• W2118096986 hasConcept C2778256501 @default.
• W2118096986 hasConcept C2780844630 @default.
• W2118096986 hasConcept C2781018059 @default.
• W2118096986 hasConcept C29537977 @default.
• W2118096986 hasConcept C502942594 @default.
• W2118096986 hasConcept C54355233 @default.
• W2118096986 hasConcept C66417403 @default.
• W2118096986 hasConcept C71924100 @default.
• W2118096986 hasConcept C81885089 @default.
• W2118096986 hasConcept C82495950 @default.
• W2118096986 hasConcept C86803240 @default.
• W2118096986 hasConcept C95444343 @default.
• W2118096986 hasConcept C97029542 @default.
• W2118096986 hasConcept C97037327 @default.
• W2118096986 hasConceptScore W2118096986C121608353 @default.
• W2118096986 hasConceptScore W2118096986C142724271 @default.
• W2118096986 hasConceptScore W2118096986C184235292 @default.
• W2118096986 hasConceptScore W2118096986C2776522094 @default.
• W2118096986 hasConceptScore W2118096986C2777176876 @default.

• next