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• W2118139638 endingPage "e11910" @default.
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• W2118139638 abstract "Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases. It is proposed that functional mitochondrial dynamics allows the exchange of compounds thereby providing a rescue mechanism.The question discussed in this paper is whether fusion and fission of mitochondria in different cell lines result in re-localization of respiratory chain (RC) complexes and of the ATP synthase. This was addressed by fusing cells containing mitochondria with respiratory complexes labelled with different fluorescent proteins and resolving their time dependent re-localization in living cells. We found a complete reshuffling of RC complexes throughout the entire chondriome in single HeLa cells within 2-3 h by organelle fusion and fission. Polykaryons of fused cells completely re-mixed their RC complexes in 10-24 h in a progressive way. In contrast to the recently described homogeneous mixing of matrix-targeted proteins or outer membrane proteins, the distribution of RC complexes and ATP synthase in fused hybrid mitochondria, however, was not homogeneous but patterned. Thus, complete equilibration of respiratory chain complexes as integral inner mitochondrial membrane complexes is a slow process compared with matrix proteins probably limited by complete fusion. In co-expressing cells, complex II is more homogenously distributed than complex I and V, resp. Indeed, this result argues for higher mobility and less integration in supercomplexes.Our results clearly demonstrate that mitochondrial fusion and fission dynamics favours the re-mixing of all RC complexes within the chondriome. This permanent mixing avoids a static situation with a fixed composition of RC complexes per mitochondrion." @default.
• W2118139638 created "2016-06-24" @default.
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• W2118139638 date "2010-07-30" @default.
• W2118139638 modified "2023-10-14" @default.
• W2118139638 title "Respiratory Chain Complexes in Dynamic Mitochondria Display a Patchy Distribution in Life Cells" @default.
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• W2118139638 doi "https://doi.org/10.1371/journal.pone.0011910" @default.
• W2118139638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2912852" @default.
• W2118139638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20689601" @default.
• W2118139638 hasPublicationYear "2010" @default.
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