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- W2118168306 abstract "One of the most controversial issues debated by cardiac electrophysiologists during the past decade has been whether programmed ventricular stimulation (PVS) plays any role in the arrhythmic risk stratification of the Brugada syndrome (BrS).1–5 The results of the multicenter study published in 2003 by the Brugada brothers were unequivocal.6 In a study involving 408 BrS individuals with no previous cardiac arrest, inducibility of ventricular fibrillation (VF) was found to be a marker of poor prognosis: individuals with inducible VF had a 6 times higher risk of having sudden death because of VF during the subsequent 2 years compared with the patients with noninducible VF. Subsequent multicenter studies from Europe7,8 and Japan,9,10 as well as 2 meta-analyses studies,11,12 failed to confirm these results,6 leading to downgrade in class indication of PVS for risk stratification from IIa in 200513 to IIb in 2013.14 However, in the latest reported meta-analysis of the prognostic value of PVS in BrS, Fauchier et al15 found that PVS actually may be useful in patients with syncope and in asymptomatic patients. The strength of that meta-analysis when compared with the first 2 reported11,12 is that it distinguished the prognostic role of PVS according to the initial clinical presentation (syncope versus asymptomatic). However, this meta-analysis did not include the results of PRogrammed ELectrical stimUlation preDictive valuE registry8 because that study did not provide data discriminating between these 2 patient groups.Article see p 777 In this issue of Circulation: Arrhythmia and Electrophysiology , Sieira et al16 analyzed the experience of Pedro Brugada laboratories in Belgium (Alst and Brussels) during the past 20 years. They reported a cohort of 404 patients with type 1 Brugada ECG (spontaneous in …" @default.
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- W2118168306 date "2015-08-01" @default.
- W2118168306 modified "2023-09-27" @default.
- W2118168306 title "Arrhythmic Risk Stratification by Programmed Ventricular Stimulation in Brugada Syndrome" @default.
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- W2118168306 doi "https://doi.org/10.1161/circep.115.003138" @default.
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