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• W2118209558 endingPage "5289" @default.
• W2118209558 startingPage "5279" @default.
• W2118209558 abstract "During development and regeneration, directed migration of cells, including neural crest cells, endothelial cells, axonal growth cones and many types of adult stem cells, to specific areas distant from their origin is necessary for their function. We have recently shown that adult skeletal muscle stem cells (satellite cells), once activated by isolation or injury, are a highly motile population with the potential to respond to multiple guidance cues, based on their expression of classical guidance receptors. We show here that, in vivo, differentiated and regenerating myofibers dynamically express a subset of ephrin guidance ligands, as well as Eph receptors. This expression has previously only been examined in the context of muscle-nerve interactions; however, we propose that it might also play a role in satellite cell-mediated muscle repair. Therefore, we investigated whether Eph-ephrin signaling would produce changes in satellite cell directional motility. Using a classical ephrin ‘stripe’ assay, we found that satellite cells respond to a subset of ephrins with repulsive behavior in vitro; patterning of differentiating myotubes is also parallel to ephrin stripes. This behavior can be replicated in a heterologous in vivo system, the hindbrain of the developing quail, in which neural crest cells are directed in streams to the branchial arches and to the forelimb of the developing quail, where presumptive limb myoblasts emigrate from the somite. We hypothesize that guidance signaling might impact multiple steps in muscle regeneration, including escape from the niche, directed migration to sites of injury, cell-cell interactions among satellite cell progeny, and differentiation and patterning of regenerated muscle." @default.
• W2118209558 created "2016-06-24" @default.
• W2118209558 creator A5002169187 @default.
• W2118209558 creator A5004021758 @default.
• W2118209558 creator A5027122064 @default.
• W2118209558 creator A5060391579 @default.
• W2118209558 date "2011-12-15" @default.
• W2118209558 modified "2023-09-26" @default.
• W2118209558 title "Eph/ephrin interactions modulate muscle satellite cell motility and patterning" @default.
• W2118209558 cites W1498522783 @default.
• W2118209558 cites W1523948508 @default.
• W2118209558 cites W1845362537 @default.
• W2118209558 cites W1850700774 @default.
• W2118209558 cites W1913092726 @default.
• W2118209558 cites W1973096186 @default.
• W2118209558 cites W1975227860 @default.
• W2118209558 cites W1977219612 @default.
• W2118209558 cites W1977745244 @default.
• W2118209558 cites W1980452947 @default.
• W2118209558 cites W1988060154 @default.
• W2118209558 cites W1992187858 @default.
• W2118209558 cites W1994526225 @default.
• W2118209558 cites W1994979780 @default.
• W2118209558 cites W1995444755 @default.
• W2118209558 cites W1997670728 @default.
• W2118209558 cites W1997946018 @default.
• W2118209558 cites W1998316378 @default.
• W2118209558 cites W1998767410 @default.
• W2118209558 cites W2001038886 @default.
• W2118209558 cites W2002178143 @default.
• W2118209558 cites W2004060475 @default.
• W2118209558 cites W2006501473 @default.
• W2118209558 cites W2007487855 @default.
• W2118209558 cites W2009266031 @default.
• W2118209558 cites W2011359270 @default.
• W2118209558 cites W2015783747 @default.
• W2118209558 cites W2018677255 @default.
• W2118209558 cites W2018723867 @default.
• W2118209558 cites W2018868080 @default.
• W2118209558 cites W2022225857 @default.
• W2118209558 cites W2022808613 @default.
• W2118209558 cites W2022926314 @default.
• W2118209558 cites W2023487301 @default.
• W2118209558 cites W2025722914 @default.
• W2118209558 cites W2028568968 @default.
• W2118209558 cites W2031489662 @default.
• W2118209558 cites W2032085080 @default.
• W2118209558 cites W2033968204 @default.
• W2118209558 cites W2038188046 @default.
• W2118209558 cites W2045471053 @default.
• W2118209558 cites W2047338936 @default.
• W2118209558 cites W2049902010 @default.
• W2118209558 cites W2052084644 @default.
• W2118209558 cites W2062408585 @default.
• W2118209558 cites W2064239827 @default.
• W2118209558 cites W2064594731 @default.
• W2118209558 cites W2064877287 @default.
• W2118209558 cites W2066091370 @default.
• W2118209558 cites W2066422154 @default.
• W2118209558 cites W2069565002 @default.
• W2118209558 cites W2070655656 @default.
• W2118209558 cites W2082144494 @default.
• W2118209558 cites W2082798625 @default.
• W2118209558 cites W2085057999 @default.
• W2118209558 cites W2085532366 @default.
• W2118209558 cites W2086543400 @default.
• W2118209558 cites W2087406252 @default.
• W2118209558 cites W2090466657 @default.
• W2118209558 cites W2091027706 @default.
• W2118209558 cites W2094191351 @default.
• W2118209558 cites W2095053887 @default.
• W2118209558 cites W2102270872 @default.
• W2118209558 cites W2103966995 @default.
• W2118209558 cites W2106449226 @default.
• W2118209558 cites W2111311963 @default.
• W2118209558 cites W2113868179 @default.
• W2118209558 cites W2117478938 @default.
• W2118209558 cites W2121764727 @default.
• W2118209558 cites W2127207681 @default.
• W2118209558 cites W2128550660 @default.
• W2118209558 cites W2134792095 @default.
• W2118209558 cites W2135890002 @default.
• W2118209558 cites W2140945282 @default.
• W2118209558 cites W2147957869 @default.
• W2118209558 cites W2151638906 @default.
• W2118209558 cites W2153080660 @default.
• W2118209558 cites W2158474463 @default.
• W2118209558 cites W2161613003 @default.
• W2118209558 cites W2170131359 @default.
• W2118209558 cites W2170872197 @default.
• W2118209558 cites W2184776738 @default.
• W2118209558 cites W2223742570 @default.
• W2118209558 cites W2288845522 @default.
• W2118209558 cites W2395713411 @default.
• W2118209558 doi "https://doi.org/10.1242/dev.068411" @default.
• W2118209558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3222207" @default.
• W2118209558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22071104" @default.
• W2118209558 hasPublicationYear "2011" @default.

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