FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118235664> ?p ?o ?g. }

• W2118235664 endingPage "1456" @default.
• W2118235664 startingPage "1443" @default.
• W2118235664 abstract "The GC content in the third codon position (GC3) exhibits a unimodal distribution in many plant and animal genomes. Interestingly, grasses and homeotherm vertebrates exhibit a unique bimodal distribution. High GC3 was previously found to be associated with variable expression, higher frequency of upstream TATA boxes, and an increase of GC3 from 5′ to 3′. Moreover, GC3-rich genes are predominant in certain gene classes and are enriched in CpG dinucleotides that are potential targets for methylation. Based on the GC3 bimodal distribution we hypothesize that GC3 has a regulatory role involving methylation and gene expression. To test that hypothesis, we selected diverse taxa (rice, thale cress, bee, and human) that varied in the modality of their GC3 distribution and tested the association between GC3, DNA methylation, and gene expression. We examine the relationship between cytosine methylation levels and GC3, gene expression, genome signature, gene length, and other gene compositional features. We find a strong negative correlation (Pearson’s correlation coefficient r = −0.67, P value < 0.0001) between GC3 and genic CpG methylation. The comparison between 5′-3′ gradients of CG3-skew and genic methylation for the taxa in the study suggests interplay between gene-body methylation and transcription-coupled cytosine deamination effect. Compositional features are correlated with methylation levels of genes in rice, thale cress, human, bee, and fruit fly (which acts as an unmethylated control). These patterns allow us to generate evolutionary hypotheses about the relationships between GC3 and methylation and how these affect expression patterns. Specifically, we propose that the opposite effects of methylation and compositional gradients along coding regions of GC3-poor and GC3-rich genes are the products of several competing processes." @default.
• W2118235664 created "2016-06-24" @default.
• W2118235664 creator A5011670317 @default.
• W2118235664 creator A5060706701 @default.
• W2118235664 creator A5066428550 @default.
• W2118235664 date "2013-07-05" @default.
• W2118235664 modified "2023-09-27" @default.
• W2118235664 title "Cross-Species Analysis of Genic GC3 Content and DNA Methylation Patterns" @default.
• W2118235664 cites W1964797108 @default.
• W2118235664 cites W1967142676 @default.
• W2118235664 cites W1984543571 @default.
• W2118235664 cites W1985624299 @default.
• W2118235664 cites W1992103955 @default.
• W2118235664 cites W1998667996 @default.
• W2118235664 cites W2004391041 @default.
• W2118235664 cites W2004477171 @default.
• W2118235664 cites W2005311687 @default.
• W2118235664 cites W2015898468 @default.
• W2118235664 cites W2024848067 @default.
• W2118235664 cites W2026935653 @default.
• W2118235664 cites W2029484950 @default.
• W2118235664 cites W2036982851 @default.
• W2118235664 cites W2042933233 @default.
• W2118235664 cites W2044484466 @default.
• W2118235664 cites W2046720335 @default.
• W2118235664 cites W2050457347 @default.
• W2118235664 cites W2050507681 @default.
• W2118235664 cites W2052707340 @default.
• W2118235664 cites W2055742349 @default.
• W2118235664 cites W2057784162 @default.
• W2118235664 cites W2071154937 @default.
• W2118235664 cites W2077562677 @default.
• W2118235664 cites W2092855609 @default.
• W2118235664 cites W2093235097 @default.
• W2118235664 cites W2100238259 @default.
• W2118235664 cites W2107337799 @default.
• W2118235664 cites W2110675844 @default.
• W2118235664 cites W2116381106 @default.
• W2118235664 cites W2120983406 @default.
• W2118235664 cites W2122752851 @default.
• W2118235664 cites W2123739134 @default.
• W2118235664 cites W2125893498 @default.
• W2118235664 cites W2126711065 @default.
• W2118235664 cites W2128171377 @default.
• W2118235664 cites W2129233532 @default.
• W2118235664 cites W2130222411 @default.
• W2118235664 cites W2130669767 @default.
• W2118235664 cites W2131573202 @default.
• W2118235664 cites W2136674578 @default.
• W2118235664 cites W2151447787 @default.
• W2118235664 cites W2156921631 @default.
• W2118235664 cites W2157344326 @default.
• W2118235664 cites W2162178715 @default.
• W2118235664 cites W2371681713 @default.
• W2118235664 cites W2460741750 @default.
• W2118235664 cites W4244288971 @default.
• W2118235664 doi "https://doi.org/10.1093/gbe/evt103" @default.
• W2118235664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3762193" @default.
• W2118235664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23833164" @default.
• W2118235664 hasPublicationYear "2013" @default.
• W2118235664 type Work @default.
• W2118235664 sameAs 2118235664 @default.
• W2118235664 citedByCount "46" @default.
• W2118235664 countsByYear W21182356642013 @default.
• W2118235664 countsByYear W21182356642014 @default.
• W2118235664 countsByYear W21182356642015 @default.
• W2118235664 countsByYear W21182356642016 @default.
• W2118235664 countsByYear W21182356642017 @default.
• W2118235664 countsByYear W21182356642018 @default.
• W2118235664 countsByYear W21182356642019 @default.
• W2118235664 countsByYear W21182356642020 @default.
• W2118235664 countsByYear W21182356642021 @default.
• W2118235664 countsByYear W21182356642022 @default.
• W2118235664 countsByYear W21182356642023 @default.
• W2118235664 crossrefType "journal-article" @default.
• W2118235664 hasAuthorship W2118235664A5011670317 @default.
• W2118235664 hasAuthorship W2118235664A5060706701 @default.
• W2118235664 hasAuthorship W2118235664A5066428550 @default.
• W2118235664 hasBestOaLocation W21182356642 @default.
• W2118235664 hasConcept C104317684 @default.
• W2118235664 hasConcept C140173407 @default.
• W2118235664 hasConcept C141231307 @default.
• W2118235664 hasConcept C150194340 @default.
• W2118235664 hasConcept C190727270 @default.
• W2118235664 hasConcept C2776023528 @default.
• W2118235664 hasConcept C33288867 @default.
• W2118235664 hasConcept C54355233 @default.
• W2118235664 hasConcept C86803240 @default.
• W2118235664 hasConceptScore W2118235664C104317684 @default.
• W2118235664 hasConceptScore W2118235664C140173407 @default.
• W2118235664 hasConceptScore W2118235664C141231307 @default.
• W2118235664 hasConceptScore W2118235664C150194340 @default.
• W2118235664 hasConceptScore W2118235664C190727270 @default.
• W2118235664 hasConceptScore W2118235664C2776023528 @default.
• W2118235664 hasConceptScore W2118235664C33288867 @default.
• W2118235664 hasConceptScore W2118235664C54355233 @default.
• W2118235664 hasConceptScore W2118235664C86803240 @default.
• W2118235664 hasIssue "8" @default.

• next