FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118279269> ?p ?o ?g. }

• W2118279269 endingPage "953" @default.
• W2118279269 startingPage "943" @default.
• W2118279269 abstract "ABSTRACT MicroRNAs play an important role in neuronal development and function. miR‐124 is the most abundantly expressed miRNA in the nervous system. Several different mRNA targets have been proposed for miR‐124, but the precise function of endogenous miR‐124 and its mRNA targets remain to be further elucidated. Specificity protein 1 (Sp1) is a transcription factor that plays key roles in many cell processes including cell cycle. However, this transcription factor is nearly absent in differentiated neurons and a remarkable suppression of Sp1 expression was shown after neurogenesis. Since miR‐124 is expressed abundantly in neurons and because Sp1 levels decrease during neurogenesis, it is possible that miR‐124 could regulate the expression of Sp1 during neuronal development. Therefore, the aim of the present study was to evaluate the putative targeting of Sp1 by miR‐124. Overexpression of miR‐124 using a plasmid coding for pri‐miR‐124 in HEK293 cells decreased the expression of Sp1 mRNA. The results of dual‐luciferase reporter assay demonstrated that miR‐124 directly targeted the 3′‐untranslated regions of Sp1 mRNA. To evaluate whether Sp1 expression was regulated by miR‐124 during the process of neuronal differentiation, Adipose‐derived mesenchymal stem cells (A‐MSCs) were differentiated into neuron‐like cells. The results of qPCR analysis showed that with the gradual increase of miR‐124 expression during neurogenesis, the expression of Sp1 mRNA decreased accordingly. In summary, this study demonstrated for the first time that miR‐124 is able to suppress Sp1 expression, which in turn affected the neuronal differentiation of mesenchymal stem cells. J. Cell. Biochem. 116: 943–953, 2015. © 2015 Wiley Periodicals, Inc." @default.
• W2118279269 created "2016-06-24" @default.
• W2118279269 creator A5005733348 @default.
• W2118279269 creator A5009674092 @default.
• W2118279269 creator A5048008412 @default.
• W2118279269 creator A5078248156 @default.
• W2118279269 creator A5084017168 @default.
• W2118279269 creator A5087194093 @default.
• W2118279269 date "2015-04-10" @default.
• W2118279269 modified "2023-10-18" @default.
• W2118279269 title "MicroRNA‐124 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Targeting Sp1 mRNA" @default.
• W2118279269 cites W1798948266 @default.
• W2118279269 cites W1812789581 @default.
• W2118279269 cites W1965306643 @default.
• W2118279269 cites W1975670052 @default.
• W2118279269 cites W1978337436 @default.
• W2118279269 cites W1996272511 @default.
• W2118279269 cites W1998117752 @default.
• W2118279269 cites W2027099269 @default.
• W2118279269 cites W2028532596 @default.
• W2118279269 cites W2038874091 @default.
• W2118279269 cites W2039141906 @default.
• W2118279269 cites W2050980456 @default.
• W2118279269 cites W2056917849 @default.
• W2118279269 cites W2059216079 @default.
• W2118279269 cites W2068926549 @default.
• W2118279269 cites W2069662100 @default.
• W2118279269 cites W2084359143 @default.
• W2118279269 cites W2085034844 @default.
• W2118279269 cites W2087962734 @default.
• W2118279269 cites W2092083785 @default.
• W2118279269 cites W2099249565 @default.
• W2118279269 cites W2100358595 @default.
• W2118279269 cites W2108401127 @default.
• W2118279269 cites W2116641097 @default.
• W2118279269 cites W2117802141 @default.
• W2118279269 cites W2133098474 @default.
• W2118279269 cites W2134965846 @default.
• W2118279269 cites W2138664009 @default.
• W2118279269 cites W2138954682 @default.
• W2118279269 cites W2141050680 @default.
• W2118279269 cites W2148042286 @default.
• W2118279269 cites W2149297993 @default.
• W2118279269 cites W2152558372 @default.
• W2118279269 cites W2161272397 @default.
• W2118279269 cites W2168230240 @default.
• W2118279269 cites W2171833185 @default.
• W2118279269 doi "https://doi.org/10.1002/jcb.25045" @default.
• W2118279269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25559917" @default.
• W2118279269 hasPublicationYear "2015" @default.
• W2118279269 type Work @default.
• W2118279269 sameAs 2118279269 @default.
• W2118279269 citedByCount "49" @default.
• W2118279269 countsByYear W21182792692015 @default.
• W2118279269 countsByYear W21182792692016 @default.
• W2118279269 countsByYear W21182792692017 @default.
• W2118279269 countsByYear W21182792692018 @default.
• W2118279269 countsByYear W21182792692019 @default.
• W2118279269 countsByYear W21182792692020 @default.
• W2118279269 countsByYear W21182792692021 @default.
• W2118279269 countsByYear W21182792692022 @default.
• W2118279269 countsByYear W21182792692023 @default.
• W2118279269 crossrefType "journal-article" @default.
• W2118279269 hasAuthorship W2118279269A5005733348 @default.
• W2118279269 hasAuthorship W2118279269A5009674092 @default.
• W2118279269 hasAuthorship W2118279269A5048008412 @default.
• W2118279269 hasAuthorship W2118279269A5078248156 @default.
• W2118279269 hasAuthorship W2118279269A5084017168 @default.
• W2118279269 hasAuthorship W2118279269A5087194093 @default.
• W2118279269 hasConcept C101762097 @default.
• W2118279269 hasConcept C104317684 @default.
• W2118279269 hasConcept C105580179 @default.
• W2118279269 hasConcept C145059251 @default.
• W2118279269 hasConcept C148738053 @default.
• W2118279269 hasConcept C150194340 @default.
• W2118279269 hasConcept C153911025 @default.
• W2118279269 hasConcept C198826908 @default.
• W2118279269 hasConcept C4746552 @default.
• W2118279269 hasConcept C54355233 @default.
• W2118279269 hasConcept C57467964 @default.
• W2118279269 hasConcept C86339819 @default.
• W2118279269 hasConcept C86803240 @default.
• W2118279269 hasConcept C95444343 @default.
• W2118279269 hasConceptScore W2118279269C101762097 @default.
• W2118279269 hasConceptScore W2118279269C104317684 @default.
• W2118279269 hasConceptScore W2118279269C105580179 @default.
• W2118279269 hasConceptScore W2118279269C145059251 @default.
• W2118279269 hasConceptScore W2118279269C148738053 @default.
• W2118279269 hasConceptScore W2118279269C150194340 @default.
• W2118279269 hasConceptScore W2118279269C153911025 @default.
• W2118279269 hasConceptScore W2118279269C198826908 @default.
• W2118279269 hasConceptScore W2118279269C4746552 @default.
• W2118279269 hasConceptScore W2118279269C54355233 @default.
• W2118279269 hasConceptScore W2118279269C57467964 @default.
• W2118279269 hasConceptScore W2118279269C86339819 @default.
• W2118279269 hasConceptScore W2118279269C86803240 @default.
• W2118279269 hasConceptScore W2118279269C95444343 @default.
• W2118279269 hasIssue "6" @default.

• next