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• W2118287467 abstract "Evaluar el efecto de la intervención farmacéutica en la identificación de los problemas relacionados con medicamentos y en la mejora de los resultados clínicos deseados; evaluar la efectividad del cinacalcet para alcanzar los objetivos clínicos recomendados por la Guía Clínica KDOQI. Estudio cuasi experimental pre-post intervención. Pacientes con hiperparatiroidismo secundario a enfermedad renal crónica, con edad ≥ 18 años y en tratamiento con cinacalcet han sido seleccionados en la farmacia externa hospitalaria entre 2007-2009. El Método Dáder de Seguimiento Farmacoterapéutico y los cuestionarios de SMAQ y Moriski, para evaluar la adherencia, han sido usados en la primera entrevista. Tras el análisis de cada caso, el farmacéutico diseñaba la intervención adecuada. Los parámetros clínicos han sido consultados en la base de datos del laboratorio del hospital. Se incluyeron 34 pacientes, detectándose al inicio 29 problemas relacionados con medicamentos, entre ellos, la no adherencia ha sido el más común (15). Tras la intervención, restaron 9 problemas relacionados con medicamentos, lo que significa que 68,9% de ellos han sido resueltos (p < 0,001), alcanzando una adherencia del 80%. Los valores séricos de parathormona, calcio y CaxP disminuyeron significativamente tras 3 meses de tratamiento (p < 0,001, < 0,001 y 0,045, respectivamente), alcanzando las recomendaciones de la Guía Clínica KDOQI. Esta intervención farmacéutica, simple y de fácil aplicabilidad, es efectiva en prevenir y resolver los problemas relacionados con medicamentos en estos pacientes, además de mejorar la adherencia al tratamiento y confirmar que cinacalcet es efectivo para lograr los resultados terapéuticos recomendados por la guía clínica KDOQI. To assess the effect of pharmaceutical intervention in the identification of drug-related problems, to improve desired clinical outcomes, and to evaluate the effectiveness of cinacalcet in achieving clinical outcomes recommended by the KDOQI Clinical Guidelines. Quasi-experimental pre-post intervention study. Patients with Secondary Hyperparathyroidism due to Chronic Kidney Disease, aged ≥18 years and under treatment with cinacalcet were recruited at the hospital outpatient pharmacy between 2007 and 2009. Dáder follow-up method and SMAQ and Moriski questionnaires were used to verify adherence at the first interview. Then, the pharmacist analyzed each case and designed an adequate intervention. Clinical parameters were consulted in the hospital laboratory data base. Thirty four patients were included, 29 drug-related problems were found before pharmacist intervention, and among these, non-adherence was the most common (15). After the intervention, 9 drug-related problems remained, which means that 68.9% of them were resolved (P<0.001), reaching an adherence of 80%. Parathyroid hormone, calcium and calcium-phosphorus product serum levels decreased significantly after 3 months of treatment (P<0.001, <0.001 and 0.045, respectively), achieving the KDOQI Clinical Guideline recommendations. These results suggest that this simple and easy-to-apply intervention was effective in preventing and resolving drug-related problems in these patients. Moreover, it improved patient adherence and confirmed that cinacalcet treatment is effective for achieving the clinical outcomes recommended by KDOQI clinical guidelines." @default.
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• W2118287467 date "2012-09-01" @default.
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• W2118287467 title "Efecto del seguimiento farmacoterapéutico en pacientes con hiperparatiroidismo secundario tratados con cinacalcet" @default.
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• W2118287467 doi "https://doi.org/10.1016/j.farma.2011.03.008" @default.
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