Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118314073> ?p ?o ?g. }
- W2118314073 endingPage "6448" @default.
- W2118314073 startingPage "6435" @default.
- W2118314073 abstract "In the nucleus, transcription factors must contend with the presence of chromatin in order to gain access to their cognate regulatory sequences. As most nuclear DNA is assembled into nucleosomes, activators must either invade a stable, preassembled nucleosome or preempt the formation of nucleosomes on newly replicated DNA, which is transiently free of histones. We have investigated the mechanism by which heat shock factor (HSF) binds to target nucleosomal heat shock elements (HSEs), using as our model a dinucleosomal heat shock promoter (hsp82-ΔHSE1). We find that activated HSF cannot bind a stable, sequence-positioned nucleosome in G1-arrested cells. It can do so readily, however, following release from G1 arrest or after the imposition of either an early S- or late G2-phase arrest. Surprisingly, despite the S-phase requirement, HSF nucleosomal binding activity is restored in the absence of hsp82 replication. These results contrast with the prevailing paradigm for activator-nucleosome interactions and implicate a nonreplicative, S-phase-specific event as a prerequisite for HSF binding to nucleosomal sites in vivo." @default.
- W2118314073 created "2016-06-24" @default.
- W2118314073 creator A5001602252 @default.
- W2118314073 creator A5007977891 @default.
- W2118314073 creator A5009655670 @default.
- W2118314073 date "2000-09-01" @default.
- W2118314073 modified "2023-10-01" @default.
- W2118314073 title "Cell Cycle-Dependent Binding of Yeast Heat Shock Factor to Nucleosomes" @default.
- W2118314073 cites W1479962123 @default.
- W2118314073 cites W1482133448 @default.
- W2118314073 cites W1504034854 @default.
- W2118314073 cites W1526483332 @default.
- W2118314073 cites W1527634862 @default.
- W2118314073 cites W1535387945 @default.
- W2118314073 cites W1540264737 @default.
- W2118314073 cites W1554360427 @default.
- W2118314073 cites W1637308698 @default.
- W2118314073 cites W1667902255 @default.
- W2118314073 cites W1776030351 @default.
- W2118314073 cites W1807079294 @default.
- W2118314073 cites W1866944746 @default.
- W2118314073 cites W1914372629 @default.
- W2118314073 cites W1926397638 @default.
- W2118314073 cites W1960503626 @default.
- W2118314073 cites W1964773769 @default.
- W2118314073 cites W1965469784 @default.
- W2118314073 cites W1967453691 @default.
- W2118314073 cites W1967769642 @default.
- W2118314073 cites W1974127944 @default.
- W2118314073 cites W1981593440 @default.
- W2118314073 cites W1984585562 @default.
- W2118314073 cites W1990000982 @default.
- W2118314073 cites W1990815031 @default.
- W2118314073 cites W1990958396 @default.
- W2118314073 cites W1993712134 @default.
- W2118314073 cites W1999939543 @default.
- W2118314073 cites W2004225662 @default.
- W2118314073 cites W2006998897 @default.
- W2118314073 cites W2008656832 @default.
- W2118314073 cites W2012531467 @default.
- W2118314073 cites W2019578579 @default.
- W2118314073 cites W2022237004 @default.
- W2118314073 cites W2031073218 @default.
- W2118314073 cites W2040385763 @default.
- W2118314073 cites W2040415752 @default.
- W2118314073 cites W2041309113 @default.
- W2118314073 cites W2051696655 @default.
- W2118314073 cites W2057894015 @default.
- W2118314073 cites W2062722074 @default.
- W2118314073 cites W2065355676 @default.
- W2118314073 cites W2065495419 @default.
- W2118314073 cites W2067746047 @default.
- W2118314073 cites W2075649709 @default.
- W2118314073 cites W2076446466 @default.
- W2118314073 cites W2081814828 @default.
- W2118314073 cites W2084601812 @default.
- W2118314073 cites W2085519410 @default.
- W2118314073 cites W2086605270 @default.
- W2118314073 cites W2100931229 @default.
- W2118314073 cites W2101599514 @default.
- W2118314073 cites W2108053853 @default.
- W2118314073 cites W2129314778 @default.
- W2118314073 cites W2132440338 @default.
- W2118314073 cites W2142157138 @default.
- W2118314073 cites W2152336037 @default.
- W2118314073 cites W2154178774 @default.
- W2118314073 cites W2155157043 @default.
- W2118314073 cites W2163550224 @default.
- W2118314073 cites W2165017561 @default.
- W2118314073 cites W2169496401 @default.
- W2118314073 cites W2170314995 @default.
- W2118314073 cites W2233385445 @default.
- W2118314073 cites W2318107156 @default.
- W2118314073 cites W2344014880 @default.
- W2118314073 cites W272039099 @default.
- W2118314073 cites W322623296 @default.
- W2118314073 doi "https://doi.org/10.1128/mcb.20.17.6435-6448.2000" @default.
- W2118314073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/86119" @default.
- W2118314073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10938121" @default.
- W2118314073 hasPublicationYear "2000" @default.
- W2118314073 type Work @default.
- W2118314073 sameAs 2118314073 @default.
- W2118314073 citedByCount "27" @default.
- W2118314073 countsByYear W21183140732012 @default.
- W2118314073 countsByYear W21183140732014 @default.
- W2118314073 countsByYear W21183140732015 @default.
- W2118314073 countsByYear W21183140732016 @default.
- W2118314073 countsByYear W21183140732018 @default.
- W2118314073 countsByYear W21183140732022 @default.
- W2118314073 crossrefType "journal-article" @default.
- W2118314073 hasAuthorship W2118314073A5001602252 @default.
- W2118314073 hasAuthorship W2118314073A5007977891 @default.
- W2118314073 hasAuthorship W2118314073A5009655670 @default.
- W2118314073 hasBestOaLocation W21183140731 @default.
- W2118314073 hasConcept C104317684 @default.
- W2118314073 hasConcept C153911025 @default.
- W2118314073 hasConcept C205260736 @default.
- W2118314073 hasConcept C52981337 @default.