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- W2118320713 abstract "Vitamin B 6 is a water soluble vitamin necessary for normal growth, development, and biological function.~'2 The physiologically active form of the vitamin, synthesized from precursors obtained through the diet, is historically known for its role as a cofactor in many enzymatic reactions regulating amino acid metabolism 3 and nervous system function. 47 In addition, the vitamin is also involved in modulating lipid metabolism, gluconeogenesis, s and immune function. 9t° While these enzymatic reactions represent the bestcharacterized functions of vitamin B 6, m o r e recent evidence suggests a role for this vitamin in a nontraditional aspect of metabolism, steroid hormone action. This novel and provocative aspect of vitamin B6 function has been suggested through indirect results obtained in several laboratories ~1 and elucidated through more direct molecular studies of the glucocorticoid hormone receptor. ~2 The purpose of this review is to present the information currently available pertaining to the relationship between vitamin B 6 and steroid hormone action. We will begin with a synopsis of the synthesis and distribution of vitamin B 6 throughout the body, followed by a brief discussion of the role of the vitamin in growth and development, neural function, and immune surveillance. We will then concentrate on the role for vitamin B 6 in steroid hormone action, ending with a speculative discussion on the future directions and significance of research in this area." @default.
- W2118320713 created "2016-06-24" @default.
- W2118320713 creator A5001320954 @default.
- W2118320713 creator A5076466340 @default.
- W2118320713 date "1991-10-01" @default.
- W2118320713 modified "2023-09-25" @default.
- W2118320713 title "Novel role for vitamin B6 in steroid hormone action: a link between nutrition and the endocrine system" @default.
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- W2118320713 doi "https://doi.org/10.1016/0955-2863(91)90052-7" @default.
- W2118320713 hasPublicationYear "1991" @default.
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