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• W2118329900 abstract "Intracellular Ca 2+ oscillations play an important role in the induction of a-MSH release from pituitary melanotrope cells of Xenopus laevis. Oscillatory, secretory and adenylyl cyclase activities are all inhibited by dopamine, neuropeptide Y (NPY) and baclofen (a GABA B receptor agonist) and stimulated by sauvagine. In this study, we test the hypothesis that these neural messengers regulate the Cat+ oscillations via a cAMP/protein kinase A (PKA)-dependent mechanism. To this end, video-imaging microscopy was applied to single Xenopus melanotropes loaded with the Ca 2+ indicator Fura-2. The cAMP-dependent PKA inhibitor H89 blocked Ca 2+ oscillations as well as the stimulatory actions of 8-Br-cAMP and sauvagine. Treatment of cells inhibited by baclofen with either 8-Br-cAMP or sauvagine led to a reappearance of Ca 2+ oscillations. A similar result was found for cells inhibited by NPY Neither 8-Br-cAMP nor sauvagine induced Cal+ oscillations in cells inhibited by dopamine. Depolarizing dopamine-inhibited cells with high potassium also failed to induce oscillations, but combining 8-Br-cAMP with membrane depolarization induced oscillations. It is concluded that sauvagine, baclofen and NPY work primarily through a cAMP/PKA-pathway while dopamine inhibits Ca 2+ oscillations in a dual fashion, namely via both a cAMP-dependent and a cAMP-independent mechanism, the latter probably involving membrane hyperpolarization." @default.
• W2118329900 created "2016-06-24" @default.
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• W2118329900 date "1996-10-01" @default.
• W2118329900 modified "2023-09-24" @default.
• W2118329900 title "Calcium oscillations in melanotrope cells of Xenopus laevis are differentially regulated by cAMPmdependent andcAMP-independent mechanisms" @default.
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• W2118329900 doi "https://doi.org/10.1016/s0143-4160(96)90038-x" @default.
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