Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118367091> ?p ?o ?g. }
- W2118367091 endingPage "5247" @default.
- W2118367091 startingPage "5238" @default.
- W2118367091 abstract "Insulin, like leptin, is considered as a lipostatic signal acting at a central level. Aging and age-associated adiposity have been related to the development of leptin resistance in Wistar rats. In the present article, hypothalamic insulin response during aging has been studied in Wistar rats. Thus, the effects of intracerebroventricular infusion of insulin during a week on food intake and body weight as well as insulin signal transduction after acute intracerebroventricular insulin administration have been studied in 3-, 8-, and 24-month-old rats. To explore the possible role of age-associated adiposity, these experiments were also performed in 8- and 24-month-old rats after 3 months of food restriction to reduce visceral adiposity index to values below those of young animals. Intracerebroventricular administration of insulin during a week was more efficient at reducing food intake and body weight in 3-month-old rats than in 8- and 24-month-old rats. Hypothalamic insulin-stimulated insulin receptor, GSK3, AKT, and p70S6K phosphorylation decreased with aging. Insulin receptor and IRS-2 phosphoserine was increased in 24-month-old rats. Food restriction improved both insulin responsiveness and insulin signaling. These data suggest that Wistar rats develop hypothalamic insulin resistance with aging. This can be explained by alterations of the signal transduction pathway. The fact that food restriction improves central insulin response and signal transduction points to the age-associated adiposity as a key player in the development of central insulin resistance." @default.
- W2118367091 created "2016-06-24" @default.
- W2118367091 creator A5001984863 @default.
- W2118367091 creator A5043937184 @default.
- W2118367091 creator A5048736770 @default.
- W2118367091 creator A5052684659 @default.
- W2118367091 creator A5063327501 @default.
- W2118367091 creator A5071416418 @default.
- W2118367091 creator A5090378159 @default.
- W2118367091 date "2007-11-01" @default.
- W2118367091 modified "2023-10-16" @default.
- W2118367091 title "Impaired Central Insulin Response in Aged Wistar Rats: Role of Adiposity" @default.
- W2118367091 cites W1967257827 @default.
- W2118367091 cites W1985352274 @default.
- W2118367091 cites W1995491925 @default.
- W2118367091 cites W1995787968 @default.
- W2118367091 cites W2001961410 @default.
- W2118367091 cites W2005890708 @default.
- W2118367091 cites W2010247670 @default.
- W2118367091 cites W2033996868 @default.
- W2118367091 cites W2037226098 @default.
- W2118367091 cites W2038066118 @default.
- W2118367091 cites W2038886993 @default.
- W2118367091 cites W2038972984 @default.
- W2118367091 cites W2039498210 @default.
- W2118367091 cites W2041872947 @default.
- W2118367091 cites W2048363513 @default.
- W2118367091 cites W2050418518 @default.
- W2118367091 cites W2050720508 @default.
- W2118367091 cites W2057386105 @default.
- W2118367091 cites W2059144308 @default.
- W2118367091 cites W2062608519 @default.
- W2118367091 cites W2069711307 @default.
- W2118367091 cites W2070100445 @default.
- W2118367091 cites W2073720428 @default.
- W2118367091 cites W2079503496 @default.
- W2118367091 cites W2085184474 @default.
- W2118367091 cites W2086773481 @default.
- W2118367091 cites W2100811284 @default.
- W2118367091 cites W2102683312 @default.
- W2118367091 cites W2102743478 @default.
- W2118367091 cites W2118166675 @default.
- W2118367091 cites W2119302231 @default.
- W2118367091 cites W2128824908 @default.
- W2118367091 cites W2139191784 @default.
- W2118367091 cites W2140691623 @default.
- W2118367091 cites W2141091098 @default.
- W2118367091 cites W2147825853 @default.
- W2118367091 cites W2160234571 @default.
- W2118367091 doi "https://doi.org/10.1210/en.2007-0543" @default.
- W2118367091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17673515" @default.
- W2118367091 hasPublicationYear "2007" @default.
- W2118367091 type Work @default.
- W2118367091 sameAs 2118367091 @default.
- W2118367091 citedByCount "42" @default.
- W2118367091 countsByYear W21183670912012 @default.
- W2118367091 countsByYear W21183670912013 @default.
- W2118367091 countsByYear W21183670912014 @default.
- W2118367091 countsByYear W21183670912015 @default.
- W2118367091 countsByYear W21183670912016 @default.
- W2118367091 countsByYear W21183670912017 @default.
- W2118367091 countsByYear W21183670912018 @default.
- W2118367091 countsByYear W21183670912019 @default.
- W2118367091 countsByYear W21183670912020 @default.
- W2118367091 countsByYear W21183670912021 @default.
- W2118367091 countsByYear W21183670912022 @default.
- W2118367091 crossrefType "journal-article" @default.
- W2118367091 hasAuthorship W2118367091A5001984863 @default.
- W2118367091 hasAuthorship W2118367091A5043937184 @default.
- W2118367091 hasAuthorship W2118367091A5048736770 @default.
- W2118367091 hasAuthorship W2118367091A5052684659 @default.
- W2118367091 hasAuthorship W2118367091A5063327501 @default.
- W2118367091 hasAuthorship W2118367091A5071416418 @default.
- W2118367091 hasAuthorship W2118367091A5090378159 @default.
- W2118367091 hasBestOaLocation W21183670911 @default.
- W2118367091 hasConcept C112446052 @default.
- W2118367091 hasConcept C126322002 @default.
- W2118367091 hasConcept C134018914 @default.
- W2118367091 hasConcept C2777391703 @default.
- W2118367091 hasConcept C2779306644 @default.
- W2118367091 hasConcept C2780613262 @default.
- W2118367091 hasConcept C511355011 @default.
- W2118367091 hasConcept C71924100 @default.
- W2118367091 hasConceptScore W2118367091C112446052 @default.
- W2118367091 hasConceptScore W2118367091C126322002 @default.
- W2118367091 hasConceptScore W2118367091C134018914 @default.
- W2118367091 hasConceptScore W2118367091C2777391703 @default.
- W2118367091 hasConceptScore W2118367091C2779306644 @default.
- W2118367091 hasConceptScore W2118367091C2780613262 @default.
- W2118367091 hasConceptScore W2118367091C511355011 @default.
- W2118367091 hasConceptScore W2118367091C71924100 @default.
- W2118367091 hasIssue "11" @default.
- W2118367091 hasLocation W21183670911 @default.
- W2118367091 hasLocation W21183670912 @default.
- W2118367091 hasLocation W21183670913 @default.
- W2118367091 hasOpenAccess W2118367091 @default.
- W2118367091 hasPrimaryLocation W21183670911 @default.
- W2118367091 hasRelatedWork W1985226700 @default.