FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118377648> ?p ?o ?g. }

• W2118377648 endingPage "426" @default.
• W2118377648 startingPage "418" @default.
• W2118377648 abstract "Cadmium is an environmental toxicant whose exposure is associated with multiple human pathologies. To prevent cadmium-induced toxicity, organisms produce a variety of detoxification molecules. In response to cadmium, the nematode Caenorhabditis elegans increases the steady-state levels of several hundred genes, including two metallothioneins, mtl-1 and mtl-2, and the cadmium-specific response gene, cdr-1. Despite the presumed importance in metal detoxification of mtl-1 and mtl-2, knockdown of their expression does not increase cadmium hypersensitivity, which suggests that these genes are not required for resistance to metal toxicity in C. elegans. To determine whether cdr-1 is critical in metal detoxification and compensates for the loss of mtl-1 and/or mtl-2, C. elegans strains were generated in which one, two, and all three genes were deleted, and the effects of cadmium on brood size, embryonic lethality, the Bag phenotype, and growth were determined. Growth at low cadmium concentrations was the only endpoint in which the triple mutant displayed more sensitivity than the single and double mutants. A lack of hypersensitivity in these strains suggests that other factors may be involved in the response to cadmium. Caenorhabditis elegans produces phytochelatins (PCs) that are critical in the defense against cadmium toxicity. PC levels in wild type, cdr-1 single, mtl-1, mtl-2 double, and triple mutants were measured. PC levels were constitutively higher in the mtl-1, mtl-2 double, and triple mutants compared with wild type. Following cadmium exposure, PC levels increased. The lack of cadmium hypersensitivity when these genes are deleted may be attributed to the compensatory effects of increases in PCs." @default.
• W2118377648 created "2016-06-24" @default.
• W2118377648 creator A5018245635 @default.
• W2118377648 creator A5052369153 @default.
• W2118377648 creator A5080296967 @default.
• W2118377648 date "2012-05-02" @default.
• W2118377648 modified "2023-10-02" @default.
• W2118377648 title "Role of MTL-1, MTL-2, and CDR-1 in Mediating CadmiumSensitivity in Caenorhabditis elegans" @default.
• W2118377648 cites W1528606854 @default.
• W2118377648 cites W1572224339 @default.
• W2118377648 cites W1588947966 @default.
• W2118377648 cites W1664552158 @default.
• W2118377648 cites W1971056228 @default.
• W2118377648 cites W1982557516 @default.
• W2118377648 cites W1992256486 @default.
• W2118377648 cites W1997052628 @default.
• W2118377648 cites W1997647894 @default.
• W2118377648 cites W1998398302 @default.
• W2118377648 cites W2011424178 @default.
• W2118377648 cites W2012384644 @default.
• W2118377648 cites W2012648167 @default.
• W2118377648 cites W2020744093 @default.
• W2118377648 cites W2021021540 @default.
• W2118377648 cites W2021645288 @default.
• W2118377648 cites W2034924573 @default.
• W2118377648 cites W2035915822 @default.
• W2118377648 cites W2057621057 @default.
• W2118377648 cites W2057923423 @default.
• W2118377648 cites W2067084274 @default.
• W2118377648 cites W2072687304 @default.
• W2118377648 cites W2078691071 @default.
• W2118377648 cites W2089799301 @default.
• W2118377648 cites W2094896724 @default.
• W2118377648 cites W2108373851 @default.
• W2118377648 cites W2130385250 @default.
• W2118377648 cites W2132556925 @default.
• W2118377648 cites W2150149910 @default.
• W2118377648 cites W2163601036 @default.
• W2118377648 cites W3022365501 @default.
• W2118377648 cites W3190406687 @default.
• W2118377648 doi "https://doi.org/10.1093/toxsci/kfs166" @default.
• W2118377648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3493192" @default.
• W2118377648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22552775" @default.
• W2118377648 hasPublicationYear "2012" @default.
• W2118377648 type Work @default.
• W2118377648 sameAs 2118377648 @default.
• W2118377648 citedByCount "33" @default.
• W2118377648 countsByYear W21183776482013 @default.
• W2118377648 countsByYear W21183776482014 @default.
• W2118377648 countsByYear W21183776482015 @default.
• W2118377648 countsByYear W21183776482016 @default.
• W2118377648 countsByYear W21183776482017 @default.
• W2118377648 countsByYear W21183776482018 @default.
• W2118377648 countsByYear W21183776482019 @default.
• W2118377648 countsByYear W21183776482020 @default.
• W2118377648 countsByYear W21183776482021 @default.
• W2118377648 countsByYear W21183776482022 @default.
• W2118377648 countsByYear W21183776482023 @default.
• W2118377648 crossrefType "journal-article" @default.
• W2118377648 hasAuthorship W2118377648A5018245635 @default.
• W2118377648 hasAuthorship W2118377648A5052369153 @default.
• W2118377648 hasAuthorship W2118377648A5080296967 @default.
• W2118377648 hasBestOaLocation W21183776481 @default.
• W2118377648 hasConcept C104317684 @default.
• W2118377648 hasConcept C127716648 @default.
• W2118377648 hasConcept C143065580 @default.
• W2118377648 hasConcept C153911025 @default.
• W2118377648 hasConcept C173396325 @default.
• W2118377648 hasConcept C178790620 @default.
• W2118377648 hasConcept C185592680 @default.
• W2118377648 hasConcept C2778944004 @default.
• W2118377648 hasConcept C2780473477 @default.
• W2118377648 hasConcept C29730261 @default.
• W2118377648 hasConcept C54355233 @default.
• W2118377648 hasConcept C544657597 @default.
• W2118377648 hasConcept C86803240 @default.
• W2118377648 hasConcept C95444343 @default.
• W2118377648 hasConceptScore W2118377648C104317684 @default.
• W2118377648 hasConceptScore W2118377648C127716648 @default.
• W2118377648 hasConceptScore W2118377648C143065580 @default.
• W2118377648 hasConceptScore W2118377648C153911025 @default.
• W2118377648 hasConceptScore W2118377648C173396325 @default.
• W2118377648 hasConceptScore W2118377648C178790620 @default.
• W2118377648 hasConceptScore W2118377648C185592680 @default.
• W2118377648 hasConceptScore W2118377648C2778944004 @default.
• W2118377648 hasConceptScore W2118377648C2780473477 @default.
• W2118377648 hasConceptScore W2118377648C29730261 @default.
• W2118377648 hasConceptScore W2118377648C54355233 @default.
• W2118377648 hasConceptScore W2118377648C544657597 @default.
• W2118377648 hasConceptScore W2118377648C86803240 @default.
• W2118377648 hasConceptScore W2118377648C95444343 @default.
• W2118377648 hasIssue "2" @default.
• W2118377648 hasLocation W21183776481 @default.
• W2118377648 hasLocation W21183776482 @default.
• W2118377648 hasLocation W21183776483 @default.
• W2118377648 hasLocation W21183776484 @default.
• W2118377648 hasOpenAccess W2118377648 @default.
• W2118377648 hasPrimaryLocation W21183776481 @default.

• next