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• W2118379843 abstract "Injury to stratified epithelia causes a strong induction of keratins 6 (K6) and 16 (K16) in post-mitotic keratinocytes located at the wound edge. We show that induction of K6 and K16 occurs within 6 h after injury to human epidermis. Their subsequent accumulation in keratinocytes correlates with the profound reorganization of keratin filaments from a pan-cytoplasmic distribution to one in which filaments are aggregated in a juxtanuclear location, opposite to the direction of cell migration. This filament reorganization coincides with additional cytoarchitectural changes and the onset of re-epithelialization after 18 h post-injury. By following the assembly of K6 and K16 in vitro and in cultured cells, we find that relative to K5 and K14, a well-characterized keratin pair that is constitutively expressed in epidermis, K6 and K16 polymerize into short 10-nm filaments that accumulate near the nucleus, a property arising from K16. Forced expression of human K16 in skin keratinocytes of transgenic mice causes a retraction of keratin filaments from the cell periphery, often in a polarized fashion. These results imply that K16 may not have a primary structural function akin to epidermal keratins. Rather, they suggest that in the context of epidermal wound healing, the function of K16 could be to promote a reorganization of the cytoplasmic array of keratin filaments, an event that precedes the onset of keratinocyte migration into the wound site." @default.
• W2118379843 created "2016-06-24" @default.
• W2118379843 creator A5027999029 @default.
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• W2118379843 date "1996-02-01" @default.
• W2118379843 modified "2023-10-11" @default.
• W2118379843 title "Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16." @default.
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• W2118379843 doi "https://doi.org/10.1083/jcb.132.3.381" @default.
• W2118379843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2120730" @default.
• W2118379843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8636216" @default.
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