FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118428474> ?p ?o ?g. }

• W2118428474 endingPage "1265" @default.
• W2118428474 startingPage "1255" @default.
• W2118428474 abstract "Hetero-oligomeric complexes of G protein-coupled receptors (GPCRs) may represent novel therapeutic targets exhibiting different pharmacology and tissue- or cell-specific site of action compared with receptor monomers or homo-oligomers. An ideal tool for validating this concept pharmacologically would be a hetero-oligomer selective ligand. We set out to develop and execute a 1536-well high-throughput screen of over 1 million compounds to detect potential hetero-oligomer selective ligands using a β-arrestin recruitment assay in U2OS cells coexpressing recombinant µ- and δ-opioid receptors. Hetero-oligomer selective ligands may bind to orthosteric or allosteric sites, and we might anticipate that the formation of hetero-oligomers may provide novel allosteric binding pockets for ligand binding. Therefore, our goal was to execute the screen in such a way as to identify positive allosteric modulators (PAMs) as well as agonists for µ, δ, and hetero-oligomeric receptors. While no hetero-oligomer selective ligands were identified (based on our selection criteria), this single screen did identify numerous µ- and δ-selective agonists and PAMs as well as nonselective agonists and PAMs. To our knowledge, these are the first µ- and δ-opioid receptor PAMs described in the literature." @default.
• W2118428474 created "2016-06-24" @default.
• W2118428474 creator A5011003940 @default.
• W2118428474 creator A5017791212 @default.
• W2118428474 creator A5040519903 @default.
• W2118428474 creator A5050634038 @default.
• W2118428474 creator A5055625413 @default.
• W2118428474 creator A5071192053 @default.
• W2118428474 creator A5087065312 @default.
• W2118428474 date "2014-10-01" @default.
• W2118428474 modified "2023-10-05" @default.
• W2118428474 title "Identification of Selective Agonists and Positive Allosteric Modulators for µ- and δ-Opioid Receptors from a Single High-Throughput Screen" @default.
• W2118428474 cites W1984107341 @default.
• W2118428474 cites W1987634950 @default.
• W2118428474 cites W2004120139 @default.
• W2118428474 cites W2011973680 @default.
• W2118428474 cites W2018269399 @default.
• W2118428474 cites W2027591014 @default.
• W2118428474 cites W2043223442 @default.
• W2118428474 cites W2055653516 @default.
• W2118428474 cites W2059628641 @default.
• W2118428474 cites W2059792931 @default.
• W2118428474 cites W2066729230 @default.
• W2118428474 cites W2086618906 @default.
• W2118428474 cites W2087372220 @default.
• W2118428474 cites W2098109575 @default.
• W2118428474 cites W2104065746 @default.
• W2118428474 cites W2104138802 @default.
• W2118428474 cites W2104930749 @default.
• W2118428474 cites W2122484765 @default.
• W2118428474 cites W2126041445 @default.
• W2118428474 cites W2129384252 @default.
• W2118428474 cites W2138325877 @default.
• W2118428474 cites W2157888970 @default.
• W2118428474 cites W2162337394 @default.
• W2118428474 cites W2165671231 @default.
• W2118428474 cites W2167673522 @default.
• W2118428474 cites W2403724604 @default.
• W2118428474 cites W3025891904 @default.
• W2118428474 cites W4230381786 @default.
• W2118428474 doi "https://doi.org/10.1177/1087057114542975" @default.
• W2118428474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047277" @default.
• W2118428474 hasPublicationYear "2014" @default.
• W2118428474 type Work @default.
• W2118428474 sameAs 2118428474 @default.
• W2118428474 citedByCount "27" @default.
• W2118428474 countsByYear W21184284742015 @default.
• W2118428474 countsByYear W21184284742016 @default.
• W2118428474 countsByYear W21184284742017 @default.
• W2118428474 countsByYear W21184284742018 @default.
• W2118428474 countsByYear W21184284742019 @default.
• W2118428474 countsByYear W21184284742020 @default.
• W2118428474 countsByYear W21184284742021 @default.
• W2118428474 countsByYear W21184284742022 @default.
• W2118428474 countsByYear W21184284742023 @default.
• W2118428474 crossrefType "journal-article" @default.
• W2118428474 hasAuthorship W2118428474A5011003940 @default.
• W2118428474 hasAuthorship W2118428474A5017791212 @default.
• W2118428474 hasAuthorship W2118428474A5040519903 @default.
• W2118428474 hasAuthorship W2118428474A5050634038 @default.
• W2118428474 hasAuthorship W2118428474A5055625413 @default.
• W2118428474 hasAuthorship W2118428474A5071192053 @default.
• W2118428474 hasAuthorship W2118428474A5087065312 @default.
• W2118428474 hasBestOaLocation W21184284741 @default.
• W2118428474 hasConcept C116569031 @default.
• W2118428474 hasConcept C135285700 @default.
• W2118428474 hasConcept C166342909 @default.
• W2118428474 hasConcept C170493617 @default.
• W2118428474 hasConcept C175656101 @default.
• W2118428474 hasConcept C178790620 @default.
• W2118428474 hasConcept C185592680 @default.
• W2118428474 hasConcept C21951064 @default.
• W2118428474 hasConcept C2777066959 @default.
• W2118428474 hasConcept C2779886867 @default.
• W2118428474 hasConcept C2780642029 @default.
• W2118428474 hasConcept C2781063702 @default.
• W2118428474 hasConcept C55493867 @default.
• W2118428474 hasConcept C70721500 @default.
• W2118428474 hasConcept C86803240 @default.
• W2118428474 hasConceptScore W2118428474C116569031 @default.
• W2118428474 hasConceptScore W2118428474C135285700 @default.
• W2118428474 hasConceptScore W2118428474C166342909 @default.
• W2118428474 hasConceptScore W2118428474C170493617 @default.
• W2118428474 hasConceptScore W2118428474C175656101 @default.
• W2118428474 hasConceptScore W2118428474C178790620 @default.
• W2118428474 hasConceptScore W2118428474C185592680 @default.
• W2118428474 hasConceptScore W2118428474C21951064 @default.
• W2118428474 hasConceptScore W2118428474C2777066959 @default.
• W2118428474 hasConceptScore W2118428474C2779886867 @default.
• W2118428474 hasConceptScore W2118428474C2780642029 @default.
• W2118428474 hasConceptScore W2118428474C2781063702 @default.
• W2118428474 hasConceptScore W2118428474C55493867 @default.
• W2118428474 hasConceptScore W2118428474C70721500 @default.
• W2118428474 hasConceptScore W2118428474C86803240 @default.
• W2118428474 hasIssue "9" @default.
• W2118428474 hasLocation W21184284741 @default.
• W2118428474 hasLocation W21184284742 @default.
• W2118428474 hasOpenAccess W2118428474 @default.

• next