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• W2118435007 startingPage "H707" @default.
• W2118435007 abstract "Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones that regulate blood pressure and volume, and exert their biological actions via the natriuretic peptide receptor-A gene (Npr1). Mice lacking Npr1 (Npr(-/-)) have marked cardiac hypertrophy and fibrosis disproportionate to their increased blood pressure. This study examined the relationships between ANP and BNP gene expression, immunoreactivity and fibrosis in cardiac tissue, circulating ANP levels, and ANP and BNP mRNA during embryogenesis in Npr1(-/-) mice. Disruption of the Npr1 signaling pathway resulted in augmented ANP and BNP gene and ANP protein expression in the cardiac ventricles, most pronounced for ANP mRNA in females [414 +/- 57 in Npr1(-/-) ng/mg and 124 +/- 25 ng/mg in wild-type (WT) by Taqman assay, P < 0.001]. This increased expression was highly correlated to the degree of cardiac hypertrophy and was localized to the left ventricle (LV) inner free wall and to areas of ventricular fibrosis. In contrast, plasma ANP was significantly greater than WT in male but not female Npr1(-/-) mice. Increased ANP and BNP gene expression was observed in Npr1(-/-) embryos from 16 days of gestation. Our study suggests that cardiac ventricular expression of ANP and BNP is more closely associated with local hypertrophy and fibrosis than either systemic blood pressure or circulating ANP levels." @default.
• W2118435007 created "2016-06-24" @default.
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• W2118435007 creator A5070335657 @default.
• W2118435007 creator A5091708188 @default.
• W2118435007 date "2002-08-01" @default.
• W2118435007 modified "2023-09-25" @default.
• W2118435007 title "Ventricular expression of natriuretic peptides in<i>Npr1</i> ^−/− mice with cardiac hypertrophy and fibrosis" @default.
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• W2118435007 doi "https://doi.org/10.1152/ajpheart.00677.2001" @default.
• W2118435007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4321891" @default.
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