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• W2118447064 abstract "SUMMARY A quantitative spleen colony method is described for assay ing tumor cells in suspensions from the tissues of mice infected with Friend leukemia virus (FV) . The method depends upon the use of (C3H x C57BL)F1 hybrid mice as hosts. These animals are able to accept tumor cell transplants from parental strain C311 mice but are resistant to the spleen focus-inducing action of FV, which may be brought in with the tumor cells to be assayed. Discrete, macroscopically visible colonies were regularly formed in the spleens of normal F1 hybrid hosts within 9 days after the intravenous injection of FV-infected C3H spleen cells. Evidence is presented which establishes the fact that these spleen colonies resulted from the neoplastic proliferation of injected cells ; they were not induced in the host by virus. The mean number of colonies formed per spleen was found to be directly proportional to the number of nucleated cells in jected. Each colony was thus derived from a single entity ; this provides the basis for the assay of FV-induced tumor cells in terms of tumor colony-forming units (TCFU). FV-induced tumor cells could also be assayed on the basis of spleen colony formation in heavily irradiated mice ; spleen foci cannot be induced by FV in such animals. Specific Friend antiserum incubated in vitro with infected spleen cell suspen sions prior to their injection into irradiated hosts had a cyto toxic action on Friend antigen-containing cells only. This per mitted a distinction to be made between FV-induced tumor colonies and normal hemopoietic colonies in the spleen. For a given FV-infected cell suspension, the content of TCFU esti mated by assay in heavily irradiated mice was not significantly different from that obtained in unirradiated F1 hybrid mice." @default.
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• W2118447064 date "1968-10-01" @default.
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• W2118447064 title "A quantitative spleen colony assay method for tumor cells induced by Friend leukemia virus infection in mice." @default.
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