FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118450265> ?p ?o ?g. }

• W2118450265 endingPage "105" @default.
• W2118450265 startingPage "96" @default.
• W2118450265 abstract "This study investigated the allegedly causal relationship between microglial activation and neurofibrillary degeneration (NFD) typical of Alzheimer's disease (AD) by determining if presence of extreme microglial activation coincides with intensified NFD. We performed comparative histopathological analyses of NFD and microglial reactivity in 18 primary subjects ranging from 4 to 51 years of age. Ten of these subjects (median age 34) died from infectious disease (HIV, sepsis) and CNS trauma, while eight subjects (median age 32.5) died from non-infectious conditions (controls). Second, we also examined two 52-year-old subjects with Down syndrome where one had comorbid sepsis and the other one did not. We found that all 10 subjects with infectious/traumatic diagnoses showed severe neuroinflammation, while the 8 control subjects completely lacked neuroinflammatory changes. However, all 18 primary subjects were found to show the same early-stage, pretangle neuropathology of Braak stage 1a and 1b, that is, they exhibited primarily subcortical NFD in the locus coeruleus and sporadic lesions in the transentorhinal cortex. Similarly, the two subjects with Down syndrome showed the same high levels of NFD (Braak stage VI) irrespective of the comorbid sepsis-related neuroinflammation present in one of these individuals. Collectively, our findings show that despite rampant microglial activation in all subjects with neuroinflammatory conditions the extent of NFD is at the same level as seen in non-inflamed controls. These findings demonstrate that microglial activation does not initiate or exacerbate NFD, and we conclude that CNS inflammation is unlikely to be causally involved in the development of NFD characteristic of AD dementia. GLIA 2013;62:96–105" @default.
• W2118450265 created "2016-06-24" @default.
• W2118450265 creator A5016965073 @default.
• W2118450265 creator A5024320577 @default.
• W2118450265 creator A5044010361 @default.
• W2118450265 creator A5049320398 @default.
• W2118450265 date "2013-11-04" @default.
• W2118450265 modified "2023-10-04" @default.
• W2118450265 title "Presence of severe neuroinflammation does not intensify neurofibrillary degeneration in human brain" @default.
• W2118450265 cites W136554027 @default.
• W2118450265 cites W1595606162 @default.
• W2118450265 cites W1607135210 @default.
• W2118450265 cites W1822935226 @default.
• W2118450265 cites W1963812982 @default.
• W2118450265 cites W1963951334 @default.
• W2118450265 cites W1964684581 @default.
• W2118450265 cites W1964771590 @default.
• W2118450265 cites W1971913084 @default.
• W2118450265 cites W1972812487 @default.
• W2118450265 cites W1979755700 @default.
• W2118450265 cites W1980309511 @default.
• W2118450265 cites W1980543900 @default.
• W2118450265 cites W1981310043 @default.
• W2118450265 cites W1988254695 @default.
• W2118450265 cites W1993023011 @default.
• W2118450265 cites W1994360125 @default.
• W2118450265 cites W1998959781 @default.
• W2118450265 cites W2002436423 @default.
• W2118450265 cites W2005729509 @default.
• W2118450265 cites W2011141622 @default.
• W2118450265 cites W2019845863 @default.
• W2118450265 cites W2020391383 @default.
• W2118450265 cites W2027953622 @default.
• W2118450265 cites W2030567293 @default.
• W2118450265 cites W2033883645 @default.
• W2118450265 cites W2033966441 @default.
• W2118450265 cites W2035408187 @default.
• W2118450265 cites W2046704592 @default.
• W2118450265 cites W2052742260 @default.
• W2118450265 cites W2053116497 @default.
• W2118450265 cites W2059696821 @default.
• W2118450265 cites W2063407739 @default.
• W2118450265 cites W2065470571 @default.
• W2118450265 cites W2068872768 @default.
• W2118450265 cites W2071134735 @default.
• W2118450265 cites W2071695496 @default.
• W2118450265 cites W2071972588 @default.
• W2118450265 cites W2072210142 @default.
• W2118450265 cites W2074274825 @default.
• W2118450265 cites W2076659607 @default.
• W2118450265 cites W2078941062 @default.
• W2118450265 cites W2079756902 @default.
• W2118450265 cites W2081533023 @default.
• W2118450265 cites W2088079659 @default.
• W2118450265 cites W2093184859 @default.
• W2118450265 cites W2093381644 @default.
• W2118450265 cites W2096410114 @default.
• W2118450265 cites W2116784956 @default.
• W2118450265 cites W2127723018 @default.
• W2118450265 cites W2130063365 @default.
• W2118450265 cites W2131478918 @default.
• W2118450265 cites W2149347131 @default.
• W2118450265 cites W2171549018 @default.
• W2118450265 cites W2329276406 @default.
• W2118450265 cites W2332469551 @default.
• W2118450265 doi "https://doi.org/10.1002/glia.22589" @default.
• W2118450265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24272705" @default.
• W2118450265 hasPublicationYear "2013" @default.
• W2118450265 type Work @default.
• W2118450265 sameAs 2118450265 @default.
• W2118450265 citedByCount "19" @default.
• W2118450265 countsByYear W21184502652014 @default.
• W2118450265 countsByYear W21184502652015 @default.
• W2118450265 countsByYear W21184502652016 @default.
• W2118450265 countsByYear W21184502652017 @default.
• W2118450265 countsByYear W21184502652018 @default.
• W2118450265 countsByYear W21184502652020 @default.
• W2118450265 countsByYear W21184502652021 @default.
• W2118450265 countsByYear W21184502652022 @default.
• W2118450265 countsByYear W21184502652023 @default.
• W2118450265 crossrefType "journal-article" @default.
• W2118450265 hasAuthorship W2118450265A5016965073 @default.
• W2118450265 hasAuthorship W2118450265A5024320577 @default.
• W2118450265 hasAuthorship W2118450265A5044010361 @default.
• W2118450265 hasAuthorship W2118450265A5049320398 @default.
• W2118450265 hasConcept C118552586 @default.
• W2118450265 hasConcept C142724271 @default.
• W2118450265 hasConcept C15744967 @default.
• W2118450265 hasConcept C169760540 @default.
• W2118450265 hasConcept C203014093 @default.
• W2118450265 hasConcept C2776914184 @default.
• W2118450265 hasConcept C2778384902 @default.
• W2118450265 hasConcept C2779134260 @default.
• W2118450265 hasConcept C2779830541 @default.
• W2118450265 hasConcept C2780130745 @default.
• W2118450265 hasConcept C2781017439 @default.
• W2118450265 hasConcept C502032728 @default.
• W2118450265 hasConcept C71924100 @default.

• next