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- W2118454270 abstract "Pradimicin BMY-28864 (Pm) is an antibiotic effective against yeasts and fungi, and is known to bind mannose in the presence of Ca2+. We examined spectroscopically the mode of interactions among Pm, Ca2+, and glycosides of mannose and man-nose oligosaccharides (Manα1-OMe, Manα1-2Manα1-OMe, Manα1-3Manα1-OMe, Manα1-4Manα1-OMe, Manα1- 6Manα1-OMe, Manα1-6(Manα1-3)Manα1-OMe, and Man9GlcNAc2-Asn, a high mannose type N-linked oligosaccharide). All the mannosides interacted with Pm in the presence of Ca2+ and caused absorbance changes. The absorbance changes occurred nonlinearly with respect to the carbohydrate concentration and do not follow a simple binding isotherm equation, suggesting a unique multistep interaction mode. The concentrations that induced half the maximum absorbance change were ∼10 mM for the mono- and di-mannosides and around 1.5 mM for the trimannoside and Man9GlcNAc2-Asn. Methyl a-D-glucopyranoside, methyl a-D-galactopyranoside, lactose, and myo-inositol did not affect the absorbance of Pm up to 50 mM. Ca2+ alone also influenced the absorbance of Pm. The absorbance between 200 and 700 nm decreased hypochromically when Ca2+ was added. The concentration that gave half the maximum absorbance decrease caused by Ca2+ was around 15 µM. Our results suggest that two Pm molecules bind one Ca2+, and each Pm binds two mannosyl residues." @default.
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- W2118454270 date "1998-04-01" @default.
- W2118454270 modified "2023-10-11" @default.
- W2118454270 title "Spectroscopic studies on the interaction of pradimicin BMY-28864 with mannose derivatives" @default.
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- W2118454270 doi "https://doi.org/10.1093/glycob/8.4.407" @default.
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