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• W2118499504 abstract "Abstract Novel and diverse functions of glial cells are currently the focus of much attention [A. Volterra and J. Meldolesi (2005) Nature Rev . 6, 626–640]. Here we present evidence that rat astroglia release acetylcholinesterase (AChE) as part of their response to hypoxic damage. Exposure of astroglia to tert‐butyl hydroperoxide, and hence oxidative stress, subsequently leads to a switching in mRNA from the classical membrane‐bound T‐AChE to a preferential increase in the splice variant for a soluble form, R‐AChE, This change in expression is reflected in increased perinuclear and reduced cytoplasmic AChE staining of the insulted glial cells, with a concomitant and marked increase in extracellular secretion that peaks at 1 h post‐treatment. An analogous increase in R‐AChE, over a similar time scale, occurs in response to psychological stress [D. Kaufer et al . (1998) Nature 93, 373–377], as well as to head injury and stroke [E. Shohami et al . (1999) J. Neurotrauma 6, 365–76]. The data presented here suggest that glial cells may be key chemical intermediaries in such situations and, perhaps more generally in pathological conditions involving oxidative stress, such as neurodegeneration." @default.
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• W2118499504 date "2006-07-01" @default.
• W2118499504 modified "2023-10-12" @default.
• W2118499504 title "Astroglia up-regulate transcription and secretion of ‘readthrough’ acetylcholinesterase following oxidative stress" @default.
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• W2118499504 doi "https://doi.org/10.1111/j.1460-9568.2006.04898.x" @default.
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