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• W2118504920 endingPage "4440" @default.
• W2118504920 startingPage "4434" @default.
• W2118504920 abstract "Single-stranded DNA binding (SSB) protein binds to single-stranded DNA (ssDNA) at the lagging strand of the replication fork in Escherichia coli cells. This protein is essential for the survival of the E.coli cell, presumably because it shields the ssDNA and holds it in a suitable conformation for replication by DNA polymerase III. In this study we undertook a biophysical analysis of the interaction between the SSB protein of E.coli and the chi subunit of DNA polymerase III. Using analytical ultracentrifugation we show that at low salt concentrations there is an increase in the stability in the physical interaction between chi and an EcoSSB/ssDNA complex when compared to that of chi to EcoSSB alone. This increase in stability disappeared in high salt conditions. The sedimentation of an EcoSSB protein lacking its C-terminal 26 amino acids remains unchanged in the presence of chi, showing that chi interacts specifically with the C-terminus of EcoSSB. In DNA melting experiments we demonstrate that chi specifically enhances the ssDNA stabilization by EcoSSB. Thus, the binding of EcoSSB to chi at the replication fork prevents premature dissociation of EcoSSB from the lagging strand and thereby enhances the processivity of DNA polymerase III." @default.
• W2118504920 created "2016-06-24" @default.
• W2118504920 creator A5021746189 @default.
• W2118504920 date "2003-08-01" @default.
• W2118504920 modified "2023-10-11" @default.
• W2118504920 title "DNA polymerase III subunit ties single-stranded DNA binding protein to the bacterial replication machinery" @default.
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• W2118504920 doi "https://doi.org/10.1093/nar/gkg498" @default.
• W2118504920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/169888" @default.
• W2118504920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12888503" @default.
• W2118504920 hasPublicationYear "2003" @default.
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